Results 91 to 100 of about 21,794 (134)

Genomic and proteomic conversion of brain ischemia to Alzheimer's disease. [PDF]

Front Cell Dev Biol
Pluta R, Ułamek-Kozioł M.
europepmc   +1 more source

Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Gonzalez Corona C, Ospina Lopera P, Rowe MC, Vila-Castelar C, Giudicessi A, Malotaux V, He B, Tristão-Pereira C, Martinez JE, Osorio Asprilla L, Ramírez Gallego MS, Alzate Echeverri DP, Serna L, Ashton NJ, Cuello AC, Aguillon D, Quiroz YT.   +16 more
europepmc   +1 more source

Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways. [PDF]

Acta Neuropathol Commun
Del Ser-Badia A, Soto-Faguás CM, Vecino R, Vendrell C, Molina-Porcel L, Sánchez-Valle R, Rodríguez-Alvarez J, Vicario C, Saura CA.   +8 more
europepmc   +1 more source

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Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells

Archives of Pharmacal Research, 2005
A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 microM AP25-35, 30 mM L-glutamate and 50 microM H2O2 caused a ...
Dae Youn Hwang, Do Young Yoon, Ki Wan Oh
exaly   +3 more sources

Cloning and characterization of the presenilin-2 gene promoter

Molecular Brain Research, 1998
Mutations in the presenilin-2 (PS-2) have been shown to cause early onset Alzheimer's disease (AD) in a series of families known as the Volga Germans and in an unrelated Italian kindred. Expression of the PS-2 gene is regulated during AD, aging, development and brain injury.
K R, Pennypacker, R, Fuldner, R, Xu, H, Hernandez, D, Dawbarn, N, Mehta, J, Perez-Tur, M, Baker, M, Hutton   +8 more
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Cloning of the cDNA encoding rat presenilin-2

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
We report here the cDNA sequence of rat homologue of presenilin-2 (PS-2). The rat PS-2 cDNA encoded 448 amino acids, and the deduced amino acid sequence was highly homologous to those of the human (94.9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 ...
H, Tanahashi, T, Tabira
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Structure and alternative splicing of the Presenilin-2 gene

NeuroReport, 1996
Missense mutations in the presenilin-1 (PS-1) and presenilin-2 (PS-2) genes have been shown to be causes of autosomal dominant Alzheimer's disease (the AD3 and AD4 loci, respectively). Alternative splicing has previously been reported in the PS-1 gene.
G, Prihar, R A, Fuldner, J, Perez-Tur, S, Lincoln, K, Duff, R, Crook, J, Hardy, C A, Philips, C, Venter, C, Talbot, R F, Clark, A, Goate, J, Li, H, Potter, E, Karran, G W, Roberts, M, Hutton, M D, Adams   +17 more
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