Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis. [PDF]
Front Mol Neurosci, 2018 Naranjo R +5 more
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γ-Secretase; presenilin 2 (PSEN2; PS2) [PDF]
Science-Business eXchange, 2010 openaire +1 more source
Case Report of a 63-Year-Old Patient With Alzheimer Disease and a Novel Presenilin 2 Mutation. [PDF]
Alzheimer Dis Assoc Disord, 2019 Wells JL, Pasternak SH.
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The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. [PDF]
PLoS One, 2018 Jiang H, Newman M, Lardelli M.
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PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. [PDF]
Autophagy, 2019 Fedeli C +4 more
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Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. [PDF]
J Cell Mol Med, 2018 Stanga S +5 more
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A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. [PDF]
J Cell Biol, 2016 Ezratty EJ, Pasolli HA, Fuchs E.
europepmc +1 more source
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments. [PDF]
J Biol Chem, 2016 Meckler X, Checler F.
europepmc +1 more source
Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease. [PDF]
Int J Alzheimers Dis, 2017 Kishimoto Y +4 more
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Expression, purification and biophysical characterization of human Presenilin 2
, 2013 Presenilin proteins are part of the γ-secretase complex which consists of four different membrane proteins. This complex plays an important role in the development of Alzheimer's disease. The cleavage of APP-C99 by $\gamma$-secretase generates the amyloid beta peptide which is the major component of amyloid plaques. Presenilins are considered to be the
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