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Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage. [PDF]
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Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. [PDF]
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From mechanistic modeling to AI-driven design: computational strategies for targeting the γ-secretase complex. [PDF]
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Early onset Alzheimer's disease with V180I variant of prion protein gene and a family history of dementia: a case report. [PDF]
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ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ<sub>1-42</sub> Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer's Disease-Associated <i>psen1</i>-Deficient Zebrafish Model. [PDF]
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Neuroinflammation and Secretase Regulation in Alzheimer's Disease: From Molecular Cross-Talk to Multi-Target Therapeutics. [PDF]
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Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans. [PDF]
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Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity. [PDF]
J NeurosciDu X, Niu L, Ragan M, Fracz Z, Wang ZW.
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