Results 101 to 110 of about 21,794 (134)

Calcium binding sequences in calmyrin regulates interaction with presenilin-2

Experimental Cell Research, 2004
Calmyrin is a myristoylated calcium binding protein that contains four putative EF-hands. Calmyrin interacts with a number of proteins, including presenilin-2 (PS2). However, the biophysical properties of calmyrin, and the molecular mechanisms that regulate its binding to different partners, are not well understood. By site-directed mutagenesis and Ca2+
Jingsong, Zhu, Stacy M, Stabler, James B, Ames, Ilia, Baskakov, Mervyn J, Monteiro   +4 more
openaire   +2 more sources

Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients

Clinica Chimica Acta, 1999
The Asn141Ile mutation of the presenilin 2 gene is responsible for familial early-onset Alzheimer disease found in Volga-German kindreds. However, the genetic influence of presenilin 2 gene on sporadic Alzheimer disease remains unknown. In this study, the frequency of the mutation and genetic association with the presenilin 2 locus were investigated in
H, Tanimukai, I, Tsujio, R, Hashimoto, T, Kudo, K, Kamino, K, Shinozaki, M, Takeda   +6 more
openaire   +2 more sources

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments

Molecular Brain Research, 2001
Mutations in the genes that encode the presenilin 1 and 2 (PS1 and PS2) proteins cause the majority of familial Alzheimer's disease (FAD). Differential cleavage of the presenilins results in a generation of at least two C-terminal fragments (CTFs).
T L, Tekirian, D E, Merriam, V, Marshansky, J, Miller, A C, Crowley, H, Chan, D, Ausiello, D, Brown, J D, Buxbaum, W, Xia, W, Wasco   +10 more
openaire   +2 more sources

Regional and Cellular Localization of Presenilin-2 RNA in Rat and Human Brain

Experimental Neurology, 1997
In situ hybridization probes selective for presenilin-2 (PS-2) were used to determine the regional and cellular expression pattern of PS-2 mRNA in rat and human brain. In rat brain, the greatest expression of PS-2 mRNA is in the granule cell layers of the dentate gyrus and cerebellum.
Benkovic, Stanley A., McGowan, Eileen M., Rothwell, Nancy J., Hutton, Michael, Morgan, David G., Gordon, Marcia N.   +5 more
openaire   +3 more sources

Neurotoxic Mechanisms by Alzheimer’s Disease-Linked N141I Mutant Presenilin 2

The Journal of Pharmacology and Experimental Therapeutics, 2002
Although it has been established that oxidative stress mediates cytotoxicity by familial Alzheimer's disease (FAD)-linked mutants of presenilin (PS)1 and that pertussis toxin inhibits cytotoxicity by FAD-linked N141I-PS2, it has not been determined whether oxidative stress is involved in cytotoxicity by N141I-PS2 or which pertussis toxin-sensitive ...
Yuichi, Hashimoto, Takako, Niikura, Yuko, Ito, Yoshiko, Kita, Kenzo, Terashita, Ikuo, Nishimoto   +5 more
openaire   +2 more sources

Screening for Mutation of the Presenilin 2 Gene in Alzheimer's Disease

Dementia and Geriatric Cognitive Disorders, 1996
K, Isoe, K, Urakami, Y, Wakutani, J, Yong, Y, Adachi, K, Nakashima   +5 more
openaire   +2 more sources

Effects of presenilin 2 in the early secretory pathway

Neurobiology of Aging, 2000
Tina L. Tekirian, Janice S. Miller, David E. Merriam, Annette C. Crowley, Joseph D. Buxbaum, Weiming Xia, Wilma Wasco   +6 more
openaire   +1 more source

Repression of presenilin 2 expression by oxidative stress

Neurobiology of Aging, 2000
Roberta Ghidoni, Laura Gasparini, Antonella Alberici, Luisa Benussi, Dario Finazzi, Benerini Gatta Luisa, John H. Growdon, Giuliano Gb. Binetti   +7 more
openaire   +1 more source

Cellular Expression and Proteolytic Processing of Presenilin Proteins Is Developmentally Regulated During Neuronal Differentiation

Journal of Neurochemistry, 1997
Anja Capell, Rainer Saffrich, Jochen Walter   +2 more
exaly  

Presenilin-2

2013
openaire   +1 more source