Results 21 to 30 of about 26,399 (217)
Cells, 2019 To fight Alzheimer’s disease (AD), we should know when, where, and how brain network dysfunctions initiate. In AD mouse models, relevant information can be derived from brain electrical activity.
Alessandro Leparulo +5 more
doaj +1 more source
Neurobiology of Disease, 2020 Mutations in APP (amyloid precursor protein), PSEN1 (presenilin 1) or PSEN2 (presenilin 2) are the main cause of early-onset familial forms of Alzheimer's disease (autosomal dominant AD or ADAD).
Anna A. Pimenova, Alison M. Goate
doaj +1 more source
A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene. [PDF]
PLoS ONE, 2013 Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting visual association cortex. Most patients diagnosed with posterior cortical
Emilia J Sitek +12 more
doaj +1 more source
Village guards as “in between” in the Turkish-Kurdish conflict: Re-examining identity and position in intergroup conflict [PDF]
, 2019 The current paper utilizes new approaches in intergroup conflict studies to examine the village guard system and its role in the Turkish-Kurdish conflict in Turkey.
Acar, Yasemin Gülsüm
core +3 more sources
Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]
, 2005 In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc +5 more
core +1 more source
miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro [PDF]
, 2020 Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs).
Aoyama, Takeshi +10 more
core +2 more sources
PSEN2 (presenilin 2 (Alzheimer disease 4)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PSEN2 (presenilin 2 (Alzheimer disease 4)), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Neurobiology of Disease, 1998 A 1340-bp cDNA fragment encoding the lemurian presenilin 2 protein (PS2) was isolated from aMicrocebus murinusbrain cDNA library by PCR using oligonucleotide primers based on the nucleotide sequence of the human gene.
Alphonse Calenda +7 more
doaj +1 more source
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core +1 more source
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources