Results 41 to 50 of about 21,794 (134)

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia.
Keying Chen, Emma Pineau, Margaret Koletar, Andrea Trevisiol, Jack Simiao He, Mary Hill, Maged Goubran, John Sled, JoAnne McLaurin, Bojana Stefanovic   +9 more
wiley   +1 more source

Vulnerability of the locus coeruleus–entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC–entorhinal cortex (LC‐EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
Elouise A. Koops, Averi Giudicessi, Ana Baena, Lusiana Martinez, Nikole Bonillas‐Felix, Randy Medrano, Joyita Dutta, Isabela Gonzalez, Sergio Alvarez, David Aguillon, Yakeel T. Quiroz, Heidi I. L. Jacobs   +11 more
wiley   +1 more source

Authorship and citation trends in dementia research: A path to equitable career development for scientists

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan, Diana Karamacoska, Lokendra S. Thakur, Mouna Sawan, Angela Gomez‐Arboledas, Ines Moreno‐Gonzalez, C. Elizabeth Shaaban, Sadaf A. Milani, Giedre Milinkeviciute, Samantha M. Loi, Anika Wuestefeld, Sindhuja T. Govindarajan, Audrey Low, Giovanna Carello‐Collar, Hom L. Shreshta, Sunnie Kenowsky, Claudia K. Suemoto, Michelle M. Mielke, Shana D. Stites   +18 more
wiley   +1 more source

Tramiprosate, the Active Agent of ALZ‐801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease

Drug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT ALZ‐801, a valine‐conjugated prodrug of tramiprosate, has recently been evaluated in a Phase III trial as a potential Alzheimer's disease (AD)‐modifying therapy. Tramiprosate reduces misfolding of amyloid beta (Aβ) monomers and inhibits oligomer formation. In the present study, we investigated tramiprosate's effects on amyloidogenic processing
Kevser Biberoglu, Ozden Tacal
wiley   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Genetic Linkage for Bipolar Disorder to the Distal Region of Chromosome 19q: A Large Family Whole Genome Sequencing Study

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Background Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations.
Albert H. C. Wong, Andrew D. Paterson, Nicole M. Roslin, Elizabeth Tetzlaff, Andrew B. Sedrak, Young Zhou, Gaurav Sharma, Paul Grof, Anne Duffy   +8 more
wiley   +1 more source

Deletion of Robo4 worsens neuroinflammation in a mouse model of Alzheimer's disease

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Declines in vascular integrity are potential contributors to Alzheimer's disease (AD) as these result in increased blood–brain barrier permeability and, consequently, accelerate neuroinflammation and cognitive impairment. Roundabout guidance receptor 4 (Robo4) is primarily expressed in endothelial cells and stabilizes the vasculature, thereby ...
Abigail E. Cullen, Nick R. Winder, Byron Lee, Sahana Krishna Kumaran, Nayantara Arora, Julia R. Wolf, Grant D. Henson, Randall L. Woltjer, Ashley E. Walker   +8 more
wiley   +1 more source