Results 91 to 100 of about 40,397 (225)

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice [PDF]

, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian, Eckert, Anne, Leutner, Silke, Luckhaus, Christian, Müller, Walter E., Schindowski, Katharina, Touchet, Nathalie   +6 more
core  

TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco, Ulland, Tyler K, Zhou, Yingyue   +2 more
core   +3 more sources

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]

, 2012
Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S., Handelsman, D.J., Harvey, A.R., Martins, R.N.   +3 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The genetics of Alzheimer's disease

Clinical Interventions in Aging, 2014
Eva Bagyinszky,1 Young Chul Youn,2 Seong Soo A An,1,* SangYun Kim3,*1Department of BioNano Technology Gachon University, Gyeonggi-do, 2Department of Neurology, Chung-Ang University College of Medicine, Seoul, 3Department of Neurology, Seoul National ...
Bagyinszky E, Youn YC, An SSA, Kim SY
doaj  

Cloning of the Presenilin 2 cDNA and Its Distribution in Brain of the Primate,Microcebus murinus: Coexpression with βAPP and Tau Proteins

Neurobiology of Disease, 1998
A 1340-bp cDNA fragment encoding the lemurian presenilin 2 protein (PS2) was isolated from aMicrocebus murinusbrain cDNA library by PCR using oligonucleotide primers based on the nucleotide sequence of the human gene.
Alphonse Calenda, Nadine Mestre-Francés, Christian Czech, Laurent Pradier, Arlette Petter, Martine Perret, Noëlle Bons, Michel Bellis   +7 more
doaj   +1 more source

GPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu, Marisa N Denkinger, Menghan Liu, Katherine Gong, Yike Chen, Daniel Western, Jigyasha Timsina, Yuchen Cheng, Yunchang Xie, Rui Mu, John Budde, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Alpana Singh, Isabel Alfradique‐Dunham, Tammie L. S. Benzinger, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Joel S. Perlumtter, B Joy Snider, Meghan C. Campbell, Paul T. Kotzbauer, Nicholas J. Ashton, Carlos Cruchaga   +25 more
wiley   +1 more source

The γ-secretase complex: from structure to function

Frontiers in Cellular Neuroscience, 2014
One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein through sequential cleavage by β-
Xian eZhang, Yanfang eLi, Huaxi eXu, Huaxi eXu, Yun-Wu eZhang   +4 more
doaj   +1 more source

rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). In humans, TCT has shown promise for the early diagnosis of Alzheimer's disease.
Stephen Duncan, Sulaiman Rehman, Vladislava Segen, Irene Choi, Sami Lawrence, Om Kalani, Lisette Gold, Lillian Goldman, Sophia Ramlo, Kylene Stickel, Dylan Layfield, Thomas Wolbers, Zoran Tiganj, Ehren L. Newman   +13 more
wiley   +1 more source