Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis [PDF]
Cells, 2023 Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer’s disease (AD). Besides its role as part of the γ-secretase complex, mammalian PS2 is also involved, as an individual protein, in a growing number of cell
Lucia Barazzuol +6 more
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Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach. [PDF]
PLoS ONE, 2022 The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to neurodegeneration.
Reshma Mary Martiz +9 more
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Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer’s Disease [PDF]
Cells, 2021 Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively.
Alice Rossi +9 more
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Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα [PDF]
Nature Communications, 2022 Hyperimmunity is associated with Alzheimer disease. Here the authors show that the Presenilin 2 N141I mutation causes overproduction of clock-controlled cytokines and memory deficits through suppression of REV-ERBα gene by hypermethylation.
Hyeri Nam +12 more
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Loosening ER–Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain [PDF]
Cells, 2021 Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer’s disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide ...
Michela Rossini +3 more
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The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. [PDF]
PLoS ONE, 2018 Alzheimer's disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer's disease (fAD).
Haowei Jiang +2 more
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Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells [PDF]
Animal Cells and SystemsChronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear.
Jihyun Hong +4 more
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Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells [PDF]
Translational Neuroscience, 2016 Presenilin 1 (PS1) and PS2 are evolutionarily conserved transmembrane proteins of the aspartyl protease family. Initially, they were reported to be associated with the early onset of familial, early-onset Alzheimer’s disease.
Kumar Ashish +2 more
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Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks [PDF]
Cells, 2020 Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimately ...
Paola Pizzo +10 more
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Data on solubilization, identification, and thermal stability of human Presenilin-2 [PDF]
Data in Brief, 2018 The data presented here are related to the research article entitled “Expression, purification, and preliminary characterization of human presenilin-2'' [1].Human Presenilin-2 is the catalytic subunit of γ-secretase and a possible calcium leakage channel
Ge Yang +3 more
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