Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases [PDF]
Journal of Pharmacy and Bioallied SciencesIntroduction: Oxidative stress is an important component in the pathogenesis of Alzheimer’s disease (AD). Materils and Methods: A comparative cross-sectional study was conducted on 140 participants who made up 70 subjects diagnosed with AD and 70 ...
Dilip Raj Timalsina +2 more
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Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE [PDF]
Frontiers in Aging Neuroscience, 2023 IntroductionAlzheimer’s disease (AD) is associated with amyloid β-protein 1-42 (Aβ42) accumulation in the brain. Aβ42 and Aβ40 are the major two species generated from amyloid precursor protein.
Yuan Gao +6 more
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A Review Article on Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Alzheimer’s Disease
Journal of Pharmacy and Bioallied SciencesAmyloid-beta plaque and tau tangle buildup lead to Alzheimer’s disease (AD), a brain disorder that causes ongoing mental decline. More and more studies show that oxidative stress plays a crucial role in how AD develops and progresses. This review focuses
Dilip Raj Timalsina +2 more
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Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein [PDF]
Communications Biology, 2023 Gaussian accelerated molecular dynamics (GaMD) simulations and biochemical experiments in E.Coli provide mechanistic insight into how Presenilin-1 familial Alzheimer’s disease mutations affect structural dynamics and enzyme-substrate interactions of γ ...
Hung N. Do +4 more
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Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
Neural Regeneration Research, 2022 The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is
Mercedes A Hernandez-Sapiens +8 more
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Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. [PDF]
PLoS ONE, 2009 Much of our current understanding about neurodegenerative diseases can be attributed to the study of inherited forms of these disorders. For example, mutations in the presenilin 1 and 2 genes have been linked to early onset familial forms of Alzheimer's ...
Kinga Michno +4 more
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PLoS ONE, 2022 The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to neurodegeneration.
Reshma Mary Martiz +9 more
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Molecular Therapy: Nucleic Acids, 2022 Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer’s disease (AD) brain. The M146L mutation in the PS1 gene (PSEN1) leads to an
Evangelos Konstantinidis +16 more
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HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? [PDF]
PLoS ONE, 2011 We have used microarray-based methods of global gene expression together with quantitative PCR and Western blot analysis to identify dysregulation of genes and aberrant cellular processes in human fibroblasts and in SH-SY5Y neuroblastoma cells made HPRT ...
Tae Hyuk Kang +3 more
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Antioxidants, 2022 Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD).
Kerry C. Ryan +2 more
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