Results 41 to 50 of about 40,397 (225)
Presenilin 1 is essential for cardiac morphogenesis [PDF]
Developmental Dynamics, 2004 AbstractPresenilin 1 (PS1) is the gene responsible for the development of early‐onset familial Alzheimer's disease. PS1‐deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1‐deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ...
Mitsunari, Nakajima +3 more
openaire +2 more sources
Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Journal of Lipid Research, 2004 Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease.
Yanzhu Liu +5 more
doaj +1 more source
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. [PDF]
, 2015 BackgroundAmyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer's disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest.
Akula, Rajender +14 more
core +3 more sources
Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]
PLoS ONE, 2015 Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these ...
Rupkatha Banerjee, Shermali Gunawardena
doaj +1 more source
Presenilin-1 and Memories of the Forebrain [PDF]
Neuron, 2001 In this issue of Neuron, report that forebrain-specific Presenilin-1 conditional knockout mice show defects in enrichment-induced neurogenesis in the dentate gyrus. This defect in neurogenesis is associated with enhanced fear memory of contextual cues when animals are subjected to enrichment between training and testing.
McGuire, Sean E, Davis, Ronald L
openaire +2 more sources
Cells, 2021 Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively.
Alice Rossi +9 more
doaj +1 more source
The Nicastrin ectodomain adopts a highly thermostable structure [PDF]
, 2011 Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the ...
Beyer, Klaus +6 more
core +2 more sources
miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro [PDF]
, 2020 Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs).
Aoyama, Takeshi +10 more
core +2 more sources
Presenilins Upregulate Functional K+Channel Currents in Mammalian Cells
Neurobiology of Disease, 1998 Mutations in presenilin 1 (PS-1) and presenilin 2 (PS-2) have been linked to early onset, autosomal dominant Alzheimer's disease. Neither the normal function(s) of the presenilins nor their role(s) in mediating the devastating neurological and ...
Sacha A. Malin +4 more
doaj +1 more source