Results 21 to 30 of about 40,397 (225)
Village guards as “in between” in the Turkish-Kurdish conflict: Re-examining identity and position in intergroup conflict [PDF]
, 2019 The current paper utilizes new approaches in intergroup conflict studies to examine the village guard system and its role in the Turkish-Kurdish conflict in Turkey.
Acar, Yasemin Gülsüm
core +3 more sources
Presenilin/γ-secretase and inflammation
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
doaj +1 more source
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction [PDF]
, 2010 Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients.
Ho, Angela +5 more
core +1 more source
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities [PDF]
Journal of Biological Chemistry, 2003 Presenilin-1 (PS1) and presenilin 2 (PS2) are proposed to be transmembrane aspartyl proteases that cleave amyloid precursor protein and Notch. PS1- and PS2-mediated activities were individually characterized using blastocyst-derived (BD) cells and membranes from PS1+/--PS2-/- and PS1-/-PS2+/+ mice, respectively.
Ming-Tain, Lai +13 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2011 A common feature in the Alzheimer’s disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles.
Maria-Salud eGarcía-Ayllón +3 more
doaj +1 more source
Cell & Bioscience, 2022 Background The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD).
Cheong-Meng Chong +10 more
doaj +1 more source
Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractThe two presenilin‐1 (PS1) and presenilin‐2 (PS2) homologs are the catalytic core of the γ‐secretase complex, which has a major role in cell fate decision and Alzheimer's disease (AD) progression. Understanding the precise contribution of PS1‐ and PS2‐dependent γ‐secretases to the production of β‐amyloid peptide (Aβ) from amyloid precursor ...
Stanga S. +5 more
openaire +4 more sources
A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila [PDF]
, 2007 It has been shown that presenilin is involved in maintaining Ca(2+) homeostasis in neurons, including regulating (ER) Ca(2+) storage. From studies of primary cultures and cell lines, however, its role in stress-induced responses is still controversial ...
Fortini, M. E. +7 more
core +1 more source
Molecular Genetics & Genomic Medicine, 2020 Background Mutations of three causative genes, namely presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP), have been identified as the major causes of early‐onset familial Alzheimer's disease (EOFAD).
Qi Qin +5 more
doaj +1 more source