Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition [PDF]
Neurobiology of Disease, 2020 Patients with Alzheimer's disease (AD) experience seizures at higher rates than the general population of that age, suggesting an underexplored role of hyperexcitability in AD.
Megan Beckman +5 more
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Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology [PDF]
Frontiers in Physiology, 2017 Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive.
Sabrina Contino +11 more
doaj +2 more sources
Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis [PDF]
Frontiers in Molecular Neuroscience, 2018 Deregulated intracellular Ca2+ and protein homeostasis underlie synaptic dysfunction and are common features in neurodegenerative diseases. DREAM, also known as calsenilin or KChIP-3, is a multifunctional Ca2+ binding protein of the neuronal calcium ...
Rocío Naranjo +11 more
doaj +2 more sources
Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans [PDF]
Redox BiologyIron is a vital trace element involved in numerous physiological processes, but it becomes toxic when present in excess. Disruption of iron balance in the brain has been linked to the development of neurodegenerative diseases such as Alzheimer's disease (
Kerry C. Ryan +5 more
doaj +2 more sources
Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2. [PDF]
Sci Rep, 2018 AbstractMutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this effect.
Dhaliwal J +8 more
europepmc +4 more sources
Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. [PDF]
J Cell Mol Med, 2018 AbstractThe two presenilin‐1 (PS1) and presenilin‐2 (PS2) homologs are the catalytic core of the γ‐secretase complex, which has a major role in cell fate decision and Alzheimer's disease (AD) progression. Understanding the precise contribution of PS1‐ and PS2‐dependent γ‐secretases to the production of β‐amyloid peptide (Aβ) from amyloid precursor ...
Stanga S +5 more
europepmc +6 more sources
Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1. [PDF]
RSC Adv, 2019 We constructed a model of presenilin-2 γ-secretase in the membrane and studied it by all-atom molecular dynamics simulations. The study provides the first structural-dynamic comparison of presenilin 1 and 2 relevant to Alzheimer's disease.
Dehury B, Tang N, Blundell TL, Kepp KP.
europepmc +5 more sources
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments. [PDF]
J Biol Chem, 2016 γ-Secretase complexes achieve the production of amyloid peptides playing a key role in Alzheimer disease. These proteases have many substrates involved in important physiological functions. They are composed of two constant subunits, nicastrin and PEN2, and two variable ones, presenilin (PS1 or PS2) and APH1 (APH1aL, APH1aS, or APH1b).
Meckler X, Checler F.
europepmc +4 more sources
Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. [PDF]
PLoS ONE, 2009 Much of our current understanding about neurodegenerative diseases can be attributed to the study of inherited forms of these disorders. For example, mutations in the presenilin 1 and 2 genes have been linked to early onset familial forms of Alzheimer's ...
Kinga Michno +4 more
doaj +1 more source
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]
Neuromolecular MedBegum S +4 more
europepmc +2 more sources