Results 181 to 190 of about 40,397 (225)

Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease. [PDF]

Arch Razi Inst
Alimoradi Z, Taghian F, Jalali Dehkordi K.   +2 more
europepmc   +1 more source

High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer's disease. [PDF]

Iran J Basic Med Sci
Kordi MR, Khademi N, Zobeydi AM, Torabi S, Mahmoodifar E, Gaeini AA, Choobineh S, Pournemati P.   +7 more
europepmc   +1 more source

The role of Aß-peptide on spatial memory, EEG, auditory evoked potential and nicotinic cholinergic receptors in A/P transgenic mice (Amyloidi ß-peptidin osuus Alzheimerin taudin mallina käytettävien A/P siirtogeenisten hiirten paikkamuistihäiriössä, EEG- ja kuuloherätevastelöydöksissä sekä kolinergisissa nikotiinireseptoreissa tavatuissa muutoksissa) [PDF]

Wang, Jun
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Presenilin-1 mutations in Alzheimer's disease

Nature, 2000
Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease1 and they often produce a different disease course from sporadic Alzheimer's and another familial form associated with mutations in the gene encoding β-amyloid precursor protein2.
RUSSO, Claudio, SCHETTINI G., SAIDO T. C., HULETTE C., LIPPA C., LANNFELT L., GHETTI B., GAMBETTI P., TABATON M., TELLER J. K.   +9 more
openaire   +6 more sources

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Nature, 1999
Accumulation of the amyloid-beta protein (Abeta) in the cerebral cortex is an early and invariant event in the pathogenesis of Alzheimer's disease. The final step in the generation of Abeta from the beta-amyloid precursor protein is an apparently intramembranous proteolysis by the elusive gamma-secretase(s).
M S, Wolfe, W, Xia, B L, Ostaszewski, T S, Diehl, W T, Kimberly, D J, Selkoe   +5 more
openaire   +4 more sources

Presenilin-1 in Neuroblastoma Cells

Toxicology in Vitro, 1998
Presenilin-1 expression was investigated in Neuro-2a cells using the alphaPS1Loop antibody. The bulk of the immunoreactivity was found as the approximately 18kDa C-terminal fragment. Hydrogen peroxide treatment of the Neuro-2a cells for 24 hours resulted in a concentration-dependent cytotoxicity with a critical concentration of hydrogen peroxide of ...
C, Lindblad, H, Hedin, G, Andersson, C J, Fowler   +3 more
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Regulation of Apoptosis by Presenilin 1

Neurobiology of Aging, 1998
Familial Alzheimer's disease is transmitted as an autosomal dominant disorder and, in 5-10% of the cases, is caused by mutations in the coding regions of two homologous genes, Presenilin 1 and 2 (PS1 and PS2). Previously, we have shown that PS2, a homolog of PS1.
B, Wolozin, P, Alexander, J, Palacino
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Presenilin-1 expression in Pick's disease

Acta Neuropathologica, 1999
Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer's disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral
P, Giannakopoulos, E, Kövari, L, Buée, J, Shioi, P R, Hof, N K, Robakis, C, Bouras   +6 more
openaire   +2 more sources