Results 101 to 110 of about 3,827,941 (337)

Setting people in their environment: plant and animal remains from Anglo-Scandinavian York [PDF]

, 2004
INTRODUCTION: For the past millennium, the inhabitants of the centre of York have, whether hey knew it or not, been living on top of a compost heap in which are preserved all kinds of remains of Anglo-Scandinavian and early post-conquest life.
Hall, A., Kenward, H.
core  

Microbial Preservation and Contamination Control in the Baking Industry

Fermentation
The required processes and steps for making bread include technological and innovative concepts. The current trend is the use of less toxic compounds and green methods.
Alane Beatriz Vermelho, Jean Vinícius Moreira, Athayde Neves Junior, Claudia Ramos da Silva, V. Cardoso, Ingrid Teixeira Akamine   +5 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Bioethics: Reincarnation of Natural Philosophy in Modern Science [PDF]

, 2017
The theory of evolution of complex and comprising of human systems and algorithm for its constructing are the synthesis of evolutionary epistemology, philosophical anthropology and concrete scientific empirical basis in ...
Cheshko, Valentin Teodorovich, Glazko, Valery I., Kosova, Yulia V.   +2 more
core  

Fossil biomass preserved as graphitic carbon in a late paleoproterozoic banded iron formation metamorphosed at more than 550°C [PDF]

, 2019
Metamorphism is thought to destroy microfossils, partly through devolatilization and graphitization of biogenic organic matter. However, the extent to which there is a loss of molecular, elemental and isotope signatures from biomass during high ...
De Gregorio, BT, Drost, M, Kilcoyne, DA, Marbach, H, Nittler, L, Papineau, D, Sagar, J, Thornton, G, Thorogate, R, Wang, J   +9 more
core   +2 more sources

Retention of Mercurial Preservatives in Desiccated Biological Products [PDF]

Journal of Clinical Microbiology, 1975
A variety of bacterins, vaccines, and antisera retained greater than 90% of their original level of mercurial preservative after lyophilization, and this might influence certain uses of these products.
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

Journal of the American College of Cardiology, 2017
Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials. A greater understanding of the in vivo human processes involved, and in particular, which are the causes and which ...
Lewis, Gavin, Schelbert, Erik B, Williams, Simon G, Cunnington, Colin, Ahmed, Fozia, McDonagh, Theresa, Miller, Christopher   +6 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

DiSCmap : digitisation of special collections mapping, assessment, prioritisation. Final project report [PDF]

, 2009
Traditionally, digitisation has been led by supply rather than demand. While end users are seen as a priority they are not directly consulted about which collections they would like to have made available digitally or why.
Birrell, Duncan, Dobreva, Milena, Dunsire, Gordon, Griffiths, Jillian, Hartley, Richard, Menzies, Kathleen   +5 more
core   +1 more source