Results 131 to 140 of about 1,438,161 (234)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IEEE AccessData owners are increasingly drawn to outsource their data due to the massive processing capabilities and scalable storage offered by cloud-based Internet of Things (IoT) solutions.
Sultan Basudan, Abdulrahman Alamer
doaj +1 more source
Approaches to Data Dissemination and Preservation
, 2007 This presentation describes approaches to dissemination and preservation, including dissemination and preservation through major data-archives, self-archiving, preservation strategies and agreements, DATA-Pass, and related technologies.
openaire +2 more sources
Tools for modelling and simulating migration-based preservation
, 2010 This report describes two tools for modelling and simulating the costs and risks of using IT storage systems for the long-term archiving of file-based AV assets.
Addis, Matthew, Jacyno, Mariusz
core
A novel method for evaluating shale gas preservation conditions in an area on a regional scale
Scientific ReportsThe Youjiang Basin is the main area of the Middle Devonian shale gas resources in southern China, with complex geological conditions, diverse stratigraphic structures, low level of exploration and limited hydrocarbon geological data.
Yuzuo Liu +8 more
doaj +1 more source
The Economic Impact of the Arts, Film, History and Tourism Industries in Connecticut [PDF]
This report contains four ecnomic impact studies corresponding to the four divisions (arts, film, historic preservation, and tourism) of the Connecticut Commission on Culture & Tourism that commissioned them.
Mark Sheridan +5 more
core