Results 121 to 130 of about 1,438,161 (234)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Does Targeting a Designated Area Crowd out the other Preservation Programs’ Efforts? [PDF]

Maryland has introduced a number of land preservation programs over the past 40 years to permanently preserve resource lands. Although new programs can increase the number of acres being preserved, they might have unintended impact on land preservation ...
Liu, Xiangping, Lynch, Lori
core   +1 more source

Experimenting with the trial of a research data audit: some preliminary findings about data types, access to data and factors for long term preservation [PDF]

, 2009
Developing systems and services for the effective and efficient management of research data as well as addressing issues around their long term curation is an area of increasing activity in UK Higher Education.
Polydoratou, P.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Community-based Curate-a-Thons to Enhance Preservation of Global Genetic Biodiversity Data

International Journal of Digital Curation
Science, Technology, Engineering, and Mathematics (STEM) and Research Data Librarians collaborated with an international research team of conservation geneticists to create an instructional and practical guide combining genetic biodiversity initiatives ...
Andrea L Pritt, Briana E Wham, Rachel H Toczydlowski, Eric D Crandall   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Addressing data management training needs: a practice based approach from the UK [PDF]

, 2012
In this paper, we describe the current challenges to the effective management and preservation of research data in UK universities, and the response provided by the JISC Managing Research Data programme. This paper will discuss, inter alia, the findings
Davidson, J., Goldstein, S., Hodson, S., Molloy, L.   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preservation of Historically and Scientifically Important Geospatial Data From Venus

Earth and Space Science
A large volume of scientifically and historically important data from the early exploration of Venus is not widely available to researchers. Our work is focused on ameliorating this problem with the archival of geospatial data including radar, topography,
T. J. Austin, J. G. O'Rourke, D. M. Nelson   +2 more
doaj   +1 more source

Differential Privacy Preservation for Continuous Release of Real-Time Location Data

Entropy
Continuous real-time location data is very important in the big data era, but the privacy issues involved is also a considerable topic. It is not only necessary to protect the location privacy at each release moment, but also have to consider the impact ...
Lihui Mao, Zhengquan Xu
doaj   +1 more source