Results 71 to 80 of about 131,444 (236)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Alloy Optimization for Reducing Delayed Fracture Sensitivity of 2000 MPa Press Hardening Steel
Metals, 2020 Press hardening steel (PHS) is widely applied in current automotive body design. The trend of using PHS grades with strengths above 1500 MPa raises concerns about sensitivity to hydrogen embrittlement.
Hardy Mohrbacher, Takehide Senuma
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Mechanical Properties of Trip Aided Bainitic Ferrite TBF Steels in Production and Service Conditions
Hittite Journal of Science and Engineering, 2018 I n the automotive industry, one of the most common methods to reduce the weight of the body components is to downgage the sheets using higher strength steels. In the design phase, engineers typically use the material properties of the incoming material,
Eren Billur +6 more
doaj +1 more source
Single cell mechanics: stress stiffening and kinematic hardening
, 2007 Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the nonlinear rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic ...
A. Mogilner +10 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
High-Energy Spectral Complexity from Thermal Gradients in Black Hole Atmospheres
, 1995 We show that Compton scattering of soft photons with energies near 100 eV in thermally stratified black-hole accretion plasmas with temperatures in the range 100 keV - 1 MeV can give rise to an X-ray spectral hardening near 10 keV. This could produce the
C. D. Dermer +17 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Recent scientific research on electrothermal metallurgical processes
Записки Горного института, 2019 A wide range of industrial metallurgical heating and melting processes are carried out using electrothermal technologies. The application of electrothermal processes offers many advantages from technological, ecological and economical point of view ...
E. Baake, V. A. Shpenst
doaj +1 more source