Results 51 to 60 of about 694,618 (154)

The Negative Impact of a Non‐Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases

Journal of Surgical Oncology, Volume 133, Issue 7, Page 843-851, June 2026.
ABSTRACT Background The peritoneum is the third most prevalent location for metastases of colorectal cancer. In patients with resectable disease, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) is the preferred treatment in the Netherlands, achieving median overall survival (OS) of 36–42 months. However, during
Teun van den Heuvel, Lars van Kesteren, Simon Nienhuijs, Pim Burger, Tineke Buffart, Jurriaan Tuynman, Ignace De Hingh   +6 more
wiley   +1 more source

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

, 2016
BACKGROUND: Peritoneal carcinomatosis is an unmet therapeutic need. Several types of intraperitoneal chemotherapy have been introduced. However, hyperthermic intraperitoneal chemotherapy has limited drug distribution and poor peritoneal penetration ...
Park, YS, Kim, HH, Jung, DH, Son, SY, Shin, DJ, Oo, AM, Ahn, SH, Park, DJ   +7 more
core   +1 more source

Clinical characteristics, treatment response, and survival outcomes in melanoma patients with cavity carcinomatosis: A retrospective analysis

International Journal of Cancer, Volume 158, Issue 9, Page 2418-2428, 1 May 2026.
What's new? Cavity carcinomatosis, a late manifestation of cancer, fuels tumor formation throughout a large area, most commonly the peritoneal and pleural cavities. The condition also can lead to resistance to otherwise effective treatment strategies.
Zhongqiao Lin, Li Zhu, Yuyang Huang, Lizhu Chen, Yuping Lu, Yu Chen, Jing Lin   +6 more
wiley   +1 more source

State-of-the-Art Therapy in Peritoneal Carcinomatosis Management

Onco
This paper reviews the surgical management of peritoneal carcinomatosis as new surgical methods have been developed within the past few decades. Traditional methods included cytoreductive surgery with hyperthermic intraperitoneal chemotherapy; however, a
Elbek Fozilov, Anthony Weng, Snigdha Kanadibhotla, Nina D. Kosciuszek, Zhaosheng Jin, Sherif R. Abdel-Misih   +5 more
doaj   +1 more source

Systemic Chemotherapy Including Ramucirumab in Combination With Pressurized Intra-Peritoneal Aerosol Chemotherapy Is a Safe Treatment Option for Peritoneal Metastasis of Gastric Cancer

Frontiers in Oncology, 2021
BackgroundPressurized intraperitoneal aerosol chemotherapy (PIPAC) is a laparoscopic technique for local chemotherapy. It has been used for treatment of peritoneal metastasis of gastric cancer (PM GC) in combination with systemic therapy.
Linda Feldbrügge, Felix Gronau, Andreas Brandl, Andreas Brandl, Timo Alexander Auer, Alan Oeff, Peter Thuss-Patience, Johann Pratschke, Beate Rau   +8 more
doaj   +1 more source

Medizintechnische Entwicklung der hyperthermen Pressurized IntraPeritoneal Aerosol Chemotherapy (hPIPAC) [PDF]

Background Optimized drug delivery systems are needed for intraperitoneal chemotherapy. The aim of this study was to develop a technology for applying pressurized intraperitoneal aerosol chemotherapy (PIPAC) under hyperthermic conditions (hPIPAC ...
Bachmann (geb. Kühfuß), Christine Jana, Bachmann, Christine   +1 more
core   +1 more source

Peritoneal Immunosurgery: Immunotherapy Augmented Surgery for the Treatment of Peritoneal Cancers

Journal of Surgical Oncology, Volume 132, Issue 5, Page 789-809, October 2025.
ABSTRACT Peritoneal malignancy often indicates disruptions in multiple physiological systems resulting from widespread cancer. The heterogenous origin and dynamic nature of peritoneal cancer make it difficult to treat with standard approaches that fit into guidelines.
Ada I. Ozcan, Arianexys Aquino López, Mary K. McKenna, Malcolm K. Brenner, Alastair M. Thompson   +4 more
wiley   +1 more source

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Unresectable Peritoneal Metastases. Feasibility, Safety and Efficacy Outcomes [PDF]

, 2022
Recently, a novel method for chemotherapy administration inside the abdominal cavity gained wide attention among surgical oncologists dealing with peritoneal surface malignancies.
ROTOLO, Stefano
core  

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications

MedComm, Volume 6, Issue 10, October 2025.
Schematic diagram illustrating the comprehensive landscape of hydrogel microspheres (HMs). (A) The components of HMs. (B) Preparation technologies employed in fabricating HMs. (C) The diverse applications of HMs across different fields. (D) The therapeutic applications of HMs in the treatment of various systemic diseases, demonstrating their potential ...
Meng Yang, Yuanyuan Shi, Feng Wang, Xin Zhang, Jiayi Shao, Fan Yang, Hao Sun, Chong Zhang, Zheng Zhou, Jianyong Huang, Pengyu Lv, Patrick Shu‐Hang Yung, Jin Cheng, Hong‐Jie Huang, Jian‐Quan Wang   +14 more
wiley   +1 more source

Overcoming Drug Resistance by Taking Advantage of Physical Principles: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

, 2019
Theoretical considerations as well as comprehensive preclinical and clinical data suggest that optimizing physical parameters of intraperitoneal drug delivery might help to circumvent initial or acquired resistance of peritoneal metastasis (PM) to ...
Marc A. Reymond, Alfred Königsrainer, Giorgi Nadiradze, Yaroslav Sautkin, Frank-Jürgen Weinreich, Rami Archid, Philipp Horvath   +6 more
core   +1 more source