Results 101 to 110 of about 3,987,151 (271)
Advanced Science, EarlyView.Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He +10 more
wiley +1 more source
Pharmacological modulation and manipulation of cancer drug resistance [PDF]
, 2010 The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core +2 more sources
Frontiers in Public HealthBackgroundHIV/AIDS remains a significant public health challenge. This study aimed to investigate the molecular transmission network and drug resistance characteristics among HIV-1 infected individuals through commercial heterosexual contact in Yubei ...
Lian Ma +4 more
doaj +1 more source
Synergy of Pd Clusters and TiO2 {101} for Photocatalytic Nonoxidative Coupling of Methane
Advanced Science, EarlyView.This study presents photocatalytic nonoxidative coupling of methane over cal‐Pd0.05/TiO2{101}, achieving near 100% selectivity and long‐term stability under mild flow conditions through synergistic single atoms and clusters catalysis. ABSTRACT Photocatalytic nonoxidative coupling of methane (NOCM) offers a sustainable route to valorize CH4 into C2 ...
Jianlong Yang +2 more
wiley +1 more source
Acta Paediatrica, 2020 AbstractAimTo assess the prevalence of pretreatment drug resistance (PDR) and its association with virologic outcomes after 24 weeks of antiretroviral therapy (ART), within an urban cohort of Ugandan children.MethodsProspective observational study. Baseline and 24‐week assessments of viral load (VL) and genotypic drug resistance to nucleoside reverse ...
Sandra Soeria‐Atmadja +9 more
openaire +2 more sources
Advanced Science, EarlyView.IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou +11 more
wiley +1 more source
Advanced Science, EarlyView.Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang +7 more
wiley +1 more source
Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]
, 2010 Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core +2 more sources
The Egyptian Journal of Internal MedicineBackground Human immunodeficiency virus (HIV) infection is a worldwide health problem that contributes to hundreds of thousands of deaths each year. In Egypt, all infected people are offered treatment on diagnosis, free of charge, regardless of the CD4 ...
Hadir Okasha +7 more
doaj +1 more source
Time to overcome pretreatment HIV drug resistance [PDF]
The Lancet Infectious Diseases, 2018 Yerly Ferrillo, Sabine, Calmy, Alexandra
openaire +4 more sources