Results 121 to 130 of about 3,987,151 (271)

Molecular monitoring of resistant dhfr and dhps allelic haplotypes in Morogoro and Mvomero districts in south eastern Tanzania. [PDF]

, 2011
BACKGROUND\ud \ud Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa.
Abdullah, S, Kachur, P, Roper, C., Bloland, P., Pearce, R., Pearce, R, Mshinda, H, Mshinda, H., Malisa, A, Mutayoba, B, Roper, C, Abdullah, S., Kachur, P., Malisa, A., Mutayoba, B., Bloland, P   +15 more
core   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, M, Davey, Mary W., Davey, Mary W, Stordal, B, Britta Stordal, Mary Davey, Stordal, Britta, Stordal, B., Davey, M.   +8 more
core   +2 more sources

Network Dynamics and Evolutionary Drivers of HIV Drug Resistance in Eastern China, from 2022 to 2024

Viruses
The increasing prevalence of HIV drug resistance poses a significant challenge. This study aimed to investigate the epidemiological dynamics and molecular characteristics of pretreatment drug resistance (PDR) and acquired drug resistance in Shaoxing ...
Dongqing Cao, Hui Xing, Yi Feng, Jiafeng Zhang, Liangkang Zhou, Zhuojing Jiang, Jinkun Chen, Tingting He   +7 more
doaj   +1 more source

Pantoprazole pretreatment elevates sensitivity to vincristine in drug-resistant oral epidermoid carcinoma in vitro and in vivo

Biomedicine & Pharmacotherapy, 2019
Resistance to chemotherapeutic agents is a major cause of treatment failure in patients with oral cancer. Proton pump inhibitors (PPIs), essentially H+-K+-ATPase inhibitors which are currently used in the treatment of acid related diseases, have demonstrated promising antitumor and chemo-sensitizing efficacy.
Zhen-Ning, Lu, Zhao-Yu, Shi, Yi-Fan, Dang, Yan-Na, Cheng, Yan-Hui, Guan, Zhao-Jun, Hao, Bing, Tian, Hong-Wei, He, Xiu-Li, Guo   +8 more
openaire   +2 more sources

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia

Viruses, 2019
Pediatric human immunodeficiency virus (HIV) care in resource-limited settings remains a major challenge to achieving global HIV treatment and virologic suppression targets, in part because the administration of combination antiretroviral therapies (cART)
Birkneh Tilahun Tadesse, Olivia Tsai, Adugna Chala, Tolossa Eticha Chaka, Temesgen Eromo, Hope R. Lapointe, Bemuluyigza Baraki, Aniqa Shahid, Sintayehu Tadesse, Eyasu Makonnen, Zabrina L. Brumme, Eleni Aklillu, Chanson J. Brumme   +12 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa. [PDF]

, 2014
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and
Martin Antonio, Odin Goovaerts (138054), Martin Gninafon, Lingoupou, Fanny M, Elie Nduwamahoro (672710), Juergen Noeske (672717), Alberto Piubello (672716), Ba, Fatoumata, Cécile Uwizeye (5661748), Elie Nduwamahoro, Martin Antonio (42317), Gehre, Florian, Oumou Sow (672713), Sow, Oumou, Dissou Affolabi (470788), Kristina Fissette (672709), Gninafon, Martin, Bouke C de Jong, Sarr, Marie, Dissou Affolabi, Uwizeye, Cécile, Alberto Piubello, Mebrat Ejo, Ejo, Mebrat, de Rijk, Pim, Fanny M Lingoupou, Kristina Fissette, Merle, Corinne, Leen Rigouts (62768), Nduwamahoro, Elie, Odin Goovaerts, Mamadou Dian Barry, Barry, Mamadou Dian, Martin Gninafon (561425), Affolabi, Dissou, Goovaerts, Odin, Marie Sarr, Florian Gehre, Pim de Rijk (377868), Noeske, Juergen, Oumou Sow, Cécile Uwizeye, Fanny M. Lingoupou (672711), Piero Olliaro (35337), Fissette, Kristina, Piubello, Alberto, Corinne Merle, Florian Gehre (182718), Mamadou Dian Barry (672712), Marie Sarr (672715), Rigouts, Leen, Piero Olliaro, Fatoumata Ba, Corinne Merle (514025), Mebrat Ejo (672708), Juergen Noeske, Fatoumata Ba (672714), de Jong, Bouke C, Pim de Rijk, Bouke C de Jong (378876), Olliaro, Piero, Leen Rigouts, Antonio, Martin   +62 more
core   +1 more source

Photo‐Gated Corona Microfluidics

Advanced Science, EarlyView.
Photo‐gated corona microfluidics decouples optical programming from electric‐field actuation to enable reconfigurable manipulation on open, electrode‐pattern‐free surfaces. Near‐infrared irradiation locally melts paraffin, creating a reversible charge‐relaxation pathway that reconstructs the electric field.
Xiaxia Cui, Yiqing Liu, Xinyi Qiu, Manfei Liu, Biao Cheng, Yuan Zhou, Changguo Xue, Sheng Zhang, Xin Tang, Qiang Tang   +9 more
wiley   +1 more source