Results 141 to 150 of about 3,987,151 (271)

Is increasing pretreatment HIV drug resistance a real menace or minor detail? – Authors' reply [PDF]

The Lancet HIV, 2020
Michael H, Chung, Christine J, McGrath, Ingrid A, Beck, Ceejay, Boyce, Lisa M, Frenkel   +4 more
openaire   +2 more sources

Pretreatment out-of-pocket costs for people with drug-resistant tuberculosis in Bandung, Indonesia

PLOS One
Background People with drug-resistant tuberculosis (DR-TB) experience multiple visits to healthcare providers before DR-TB diagnosis and treatment. Our study aimed to quantify pretreatment direct costs and factors associated with higher costs among people with DR-TB.
Bony Wiem Lestari, Silvi Indriani, Adriana Viola Miranda, Dyah Ayu Nur Safira, Nur Ayu Fitriani, Raden Desy Nurhayati, Mirza Purwitasari, Almira Alifia, Alamanda Larasmanah, Iceu Dimas Kulsum, Arto Yuwono Soeroto   +10 more
openaire   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. [PDF]

Virol J, 2023
Kiros M, Biset S, Gebremariam B, Yalew GT, Abegaz WE, Geteneh A.   +5 more
europepmc   +1 more source

HIV-1 Pretreatment and Acquired Antiretroviral Drug Resistance before tenofovir/ /lamivudine /dolutegravir (TLD) roll-out in Mozambique Running title: Pretreatment and Acquired HIV Drug Resistance in Mozambique

Abstract Introduction The World Health Organization (WHO) recommends that HIV treatment scale-up is accompanied by a robust assessment of drug resistance emergence and transmission. Included in the WHO HIV Drug Resistance (HIVDR) monitoring and surveillance strategy is HIVDR testing in adults both initiating and receiving antiretroviral ...
Nália Ismael, Hernane Gemusse, Isabel Mahumane, Osvaldo Laurindo, Cacildo Magul, Cheryl Baxter, Eduan ’ Wilkinson, Nick Wagar, Dulce Bila, Nédio Mabunda, Juliana Silva, Túlio Oliveira, Elliot Raizes, Wolfgang Presier, Pedro Manuel, Artur Ramos, Adolfo Vúbil   +16 more
openaire   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology
Nongenetic adaptive resistance to chemotherapy, driven by transcriptional rewiring, is emerging as a significant mechanism in tumor survival. In this study we combined longitudinal transcriptomics with temporal pattern analysis to investigate patient ...
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
doaj   +1 more source

Impact of HIV Pretreatment Drug Resistance on Virological Failure After One-Year Antiretroviral Therapy - China, 2018-2019. [PDF]

China CDC Wkly, 2022
Li M, Song C, Dong A, Hu J, Kang R, Xing H, Ruan Y, Shao Y, Hong K, Liao L.   +9 more
europepmc   +1 more source

The Clinical Implications of Pretreatment Drug Resistance—A Moving Target

Clinical Infectious Diseases, 2018
Robert W, Shafer, Lisa M, Frenkel
openaire   +2 more sources

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source