Results 251 to 260 of about 3,987,151 (271)

Pretreatment HIV Drug Resistance Increases Regimen Switches in Sub-Saharan Africa [PDF]

open access: yesClinical Infectious Diseases, 2015
Abstract Background.  After the scale-up of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in Africa, increasing numbers of patients have pretreatment drug resistance. Methods.  In a large multicountry cohort of patients starting standard first-line ART in six African countries, pol ...
Kim C.E. Sigaloff   +2 more
exaly   +6 more sources

Pretreatment Hiv Drug Resistance in low- and middle-income Countries [PDF]

open access: yesFuture Virology, 2019
Pretreatment HIV drug resistance (PDR) has been increasing with scale-up of antiretroviral therapy (ART) in low- and middle-income countries. Delay in responding to rising levels of PDR is projected to fuel a worldwide increase in mortality, HIV incidence and ART costs.
Silvia Bertagnolio, Seth C Inzaule
exaly   +4 more sources

Prevalence of pretreatment HIV drug resistance in key populations: a systematic review and meta-analysis [PDF]

open access: yesJournal of the International AIDS Society, 2020
AbstractIntroductionWHO’s 2019 report on HIV drug resistance (HIVDR) documents a high prevalence of pretreatment drug resistance (PDR) among populations initiating first‐line antiretroviral therapy (ART) in low‐ and middle‐income countries (LMIC). However, systematic evidence on the prevalence of PDR among key populations remains limited.
Virginia Macdonald   +2 more
exaly   +3 more sources

Surveillance of Pretreatment Drug Resistance Among HIV-Infected Children in Ibadan, Nigeria

AIDS Research and Human Retroviruses, 2021
There are about 2.1 million children infected with HIV globally and about 120,000 deaths annually. Nigeria has one of the highest rates of pediatric HIV infection globally. Pretreatment HIV drug resistance data inform the choice of first- and second-line antiretroviral therapy (ART) regimens. This study investigated the prevalence of HIV drug-resistant
Fiyinfoluwa I. Olusola   +3 more
openaire   +2 more sources

HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China

AIDS Research and Human Retroviruses, 2020
Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from January 2016 to
Xiaowen Gong
exaly   +3 more sources

Pretreatment HIV-1 drug resistance in Africa

The Lancet Infectious Diseases, 2013
476 www.thelancet.com/infection Vol 13 June 2013 1 Hamers RL, Schuurman R, Sigaloff KCE, et al, for the PharmAccess African Studies to Evaluate Resistance (PASER) Investigators. Eff ect of pretreatment HIV-1 drug resistance on immunological, virological, and drugresistance outcomes of fi rst-line antiretroviral treatment in sub-Saharan Africa: a ...
Hamers, Raph L.   +3 more
openaire   +3 more sources

Pretreatment HIV-1 drug resistance testing in sub-Saharan Africa

The Lancet Infectious Diseases, 2012
www.thelancet.com/infection Vol 12 December 2012 911 of patients with tuberculosis in the Indian private sector get tested with antibody-based, serological tests that are now banned by the Government of India. Even after the ban, several private laboratories are continuing to off er tuberculosis serology, whereas others have switched to equally bad or ...
Lynen, L.   +3 more
openaire   +3 more sources

Moderate-to-High Levels of Pretreatment HIV Drug Resistance in KwaZulu-Natal Province, South Africa [PDF]

open access: yesAIDS Research and Human Retroviruses, 2019
There is evidence of increasing levels of pretreatment HIV drug resistance (PDR) in Southern Africa. We used data from two large population-based HIV surveillance studies to estimate prevalence of PDR in KwaZulu-Natal, the province with the highest HIV prevalence in South Africa.
Ayesha Kharsany   +2 more
exaly   +4 more sources

HIV pretreatment drug resistance trends in three geographic areas of Mexico

Journal of Antimicrobial Chemotherapy, 2017
Pretreatment drug resistance (PDR) levels to NNRTI approaching 10% have recently been reported in Mexico. However, subnational differences may exist in PDR prevalence and transmission dynamics.We longitudinally assessed HIV PDR in three geographic areas of Mexico.HIV-infected, antiretroviral-naive individuals were recruited from 2008 to 2016, from the ...
Claudia, García-Morales   +10 more
openaire   +2 more sources

Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study

open access: yesLancet Infectious Diseases, The, 2012
Background The effect of pretreatment HIV-1 drug resistance on the response to first-line combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed.
Kim C.E. Sigaloff   +2 more
exaly   +2 more sources

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