Results 91 to 100 of about 18,376 (235)

Cytochrome P450 2D6 *17 and *29 Allele Activity for Risperidone Metabolism: Advancing Precision Medicine Health Equity

Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 1152-1160, November 2025.
CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde, Samuel E. Vaughn, Ogochukwu Amaeze, Paul Toren, Brandon Retke, Akinyemi Oni‐Orisan, Laura B. Ramsey   +6 more
wiley   +1 more source

Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds

ChemistrySelect, Volume 10, Issue 41, November 3, 2025.
This study presents a comprehensive pipeline for screening melatonin‐inspired compounds synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) “Click Chemistry” against Plasmodium falciparum. The pipeline evaluates activity against asexual and sexual stages, cytotoxicity, and potential interference with parasite melatonin signaling ...
Abhinab Mohanty, Lamark Carlos I, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão, Celia R. S. Garcia   +4 more
wiley   +1 more source

Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study.

PLoS Medicine, 2017
BackgroundPrimaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore, preventing relapses of vivax malaria. It is a vital component of global malaria elimination efforts.
Nicholas M Douglas, Jeanne Rini Poespoprodjo, Dewi Patriani, Michael J Malloy, Enny Kenangalem, Paulus Sugiarto, Julie A Simpson, Yati Soenarto, Nicholas M Anstey, Ric N Price   +9 more
doaj   +1 more source

Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon

Brazilian Journal of Infectious Diseases, 2010
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine.
Wilson M. Ramos Júnior, José F.J. Sardinha, Mônica R.F. Costa, Marli S. Santana, Maria G.C. Alecrim, Marcus V.G. Lacerda   +5 more
doaj   +1 more source

Towards Malaria Elimination: A Nationwide Case–Control Study to Assess Risk Factors for Severe Malaria‐Related Deaths in Brazil

Tropical Medicine &International Health, Volume 30, Issue 11, Page 1194-1210, November 2025.
ABSTRACT Objective The objective of this study is to describe malaria‐related deaths and assess their risk factors. Methods This is a case–control study using data from Brazil's Ministry of Health (2011–2020) on malaria‐related deaths (ICD‐10: B50‐B54). A probabilistic record linkage was performed to match epidemiological data (Sivep‐Malaria and Sinan)
Klauss K. S. Garcia, Gabriel Z. Laporta, Elisabeth Carmen Duarte, Seyi Soremekun, Amanda Amaral Abrahão, Anderson Coutinho da Silva, Anielle de Pina Costa, Marcus Vinícius Guimarães Lacerda, Chris Drakeley, Walter Massa Ramalho, André M. Siqueira   +10 more
wiley   +1 more source

Primaquine [PDF]

Reactions Weekly, 2020
  +6 more sources

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]

, 2008
A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut, Margaret S Collins, Melanie T Cushionc, Nuno Vale, Paula Gomes, Philip J Rosenthal, Ricardo Ferraz, Rui Moreira   +7 more
core   +1 more source

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

Applied Research, Volume 4, Issue 5, October 2025.
Schematic representation of orally administered antimalarial–oligochitosan conjugates. The mucoadhesive properties of oligochitosan facilitate enhanced drug absorption across the intestinal epithelium (Image created in BioRender.com & Microsoft 365 PowerPoint).
William Matshe, Sindisiwe Mvango, Rudzani Malabi, Asongwe Tantoh, Charlene Andraos, Ibukun Famuyide, Lyndy McGaw, Sooraj Baijnath, Lynne Pilcher, Mohammed Balogun   +9 more
wiley   +1 more source

Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine

Memorias do Instituto Oswaldo Cruz
BACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads.
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy   +1 more
doaj   +1 more source

Autophagy‐Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy

Exploration, Volume 5, Issue 5, October 2025.
This review emphasizes the critical role of autophagy in cancer treatment, highlighting the development of autophagy‐targeting nanomedicines and their applications in combination therapies. It explores how nanoplatforms can effectively regulate autophagy, underscoring the potential of integrating autophagy modulation with other treatment strategies to ...
Zhouyi Sun, Huali Zuo, Kai Zhang, Yang Liu, Qianwen Wang, Qitao Hu, Jiwei Qian, Andreas Lundqvist, Bo Zhang, Weiyu Chen, Zhe Tang   +10 more
wiley   +1 more source