Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by Acanthamoeba castellanii and Naegleria Fowleri [PDF]
Parasite Epidemiology and ControlAcanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Devandran Apparasamy +8 more
doaj +2 more sources
Primary Amoebic (Naegleria fowleri) Meningoencephalitis Presenting as Status Epilepticus
Online Journal of Health & Allied Sciences, 2011 Primary amebic meningoencephalitis (PAM) is a rare entity. Usual presenting features are fever, headache and seizures with meningeal signs and this disease carries high mortality rate. We present a case report of PAM presenting as status epilepticus.
A Sharma +5 more
doaj +1 more source
The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis. [PDF]
Antimicrob Agents Chemother, 2023 Ženíšková K +6 more
europepmc +2 more sources
Potential Application of Vaporized Drugs via Nasal Inhalers to Prevent Mortality and Central Nervous System Damage Caused by Primary Amoebic Meningoencephalitis Due to Naegleria fowleri. [PDF]
ACS Pharmacol Transl Sci, 2021 Here, it is proposed that nasal inhalers with specific anti-Naegleria fowleri drugs or a combination of anti-N. fowleri compounds combined with steroids such as dexamethasone could provide a practical solution for treating primary amoebic ...
Siddiqui R +4 more
europepmc +2 more sources
Clinical manifestations and outcome of patients with primary amoebic meningoencephalitis in Pakistan. A single-center experience. [PDF]
PLoS One, 2023 Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater.
Rehman SU +6 more
europepmc +2 more sources
Naegleria fowleri from Pakistan Has Type-2 Genotype
Iranian Journal of Parasitology, 2022 Background: Primary amoebic meningoencephalitis (PAM) is an acute and fulminant CNS infection caused by Naegleria fowleri. Recreational activities and ritual ablution with contaminated warm fresh water are the main reason of PAM.
Muhammad Aurongzeb +7 more
doaj +1 more source
Cases of brain eating amoeba in India: Primary amoebic meningoencephalitis clinical features and pathogenesis [PDF]
New Microbes and New InfectionsMariyam Niusha Naseer +5 more
doaj +2 more sources
Fatal primary amoebic meningoencephalitis in a Norwegian tourist returning from Thailand. [PDF]
JMM Case Rep, 2016 Stubhaug TT +8 more
europepmc +2 more sources
Advanced Synthesis &Catalysis, Volume 365, Issue 24, Page 4567-4575, December 19, 2023., 2023 Abstract A three‐step synthesis of anti‐amoebic, ring‐fused mackinazolinones has been developed. A Mannich‐type reaction between quinazolin‐4‐ones and N‐Cbz propanal in the presence of AgOTf afforded quinazolinones (19–94% isolated yield) bearing a newly formed heterocycle with an alkylamine appendage that, upon N‐Cbz deprotection and basification ...
Matthew S. Lish +5 more
wiley +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Naegleria fowleri is an opportunistic protozoan, belonging to the free-living amoeba group, that can be found in warm water bodies. It is causative agent the primary amoebic meningoencephalitis, a fulminant disease with a rapid progression that affects ...
Iñigo Arberas-Jiménez +10 more
doaj +1 more source