Results 251 to 260 of about 48,035 (283)

Primary biliary cholangitis: treatment

Current Opinion in Gastroenterology, 2021
Purpose of review To discuss the most recent data regarding treatment of patients with primary biliary cholangitis (PBC) with inadequate response to ursodeoxycholic acid (UDCA). Recent findings Patients with PBC at high-risk of progressive disease are younger, have advanced fibrosis
Cazzagon N., Floreani A.
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Autoantibodies in Primary Biliary Cholangitis

Clinics in Liver Disease, 2022
Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease characterized by a lymphocytic cholangitis, with subsequent cholestasis, progressive liver fibrosis, and ultimately complications arising from end-stage liver disease. Testing for autoantibodies is important in the diagnosis of PBC, as well as stratifying prognosis.
Kristel K, Leung, Gideon M, Hirschfield
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Primary sclerosing cholangitis and primary biliary cholangitis

InnovAiT: Education and inspiration for general practice, 2022
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare and progressive cholestatic liver diseases that can result in end-stage liver disease. It is known that PSC and PBC patients have worse health outcomes compared with the general population.
Michael Perry, Anjali Pathak
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Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

American Journal of Gastroenterology, 2019
Cholestatic liver diseases encompass a broad spectrum of pathologies, with the core injury occurring at the level of cholangiocytes and progressing to hepatic fibrosis and liver dysfunction. Primary biliary cholangitis and primary sclerosing cholangitis are the most significant progressive cholangiopathies in adults. Although rare, they commonly evolve
Raquel T, Yokoda, Elizabeth J, Carey
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Primary biliary cholangitis in China

Current Opinion in Gastroenterology, 2016
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by immunomediated destruction of small and medium-sized intrahepatic bile ducts. In 1987, a cDNA for a 74 kDa mitochondrial autoantigen was cloned and identified as the E2 component of the mitochondrial pyruvate dehydrogenase complex, which improved the diagnosis and
Lifeng, Wang, M Eric, Gershwin, Fu-Sheng, Wang   +2 more
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Epigenetics of Primary Biliary Cholangitis

2020
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with non-suppurative destruction of the intrahepatic bile ducts. The interplay of genetics and environmental triggers contributes to the onset of the disease and subsequently results in cholestasis and progressive fibrosis.
Yikang, Li, Ruqi, Tang, Xiong, Ma
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The genetics of primary biliary cholangitis

Current Opinion in Gastroenterology, 2019
Primary biliary cholangitis (PBC) is a female predominant chronic autoimmune disease of the intrahepatic bile ducts and with a long latent period. It is crucial to understand how genetics contribute to the disease.Geo-epidemiological studies in PBC have provided evidence of familial risk; case-control studies and genome wide association studies have ...
Atsushi, Tanaka, Patrick S C, Leung, Merrill Eric, Gershwin   +2 more
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Progress in Primary Biliary Cholangitis

New England Journal of Medicine, 2018
Primary biliary cholangitis remains an incurable disease. The first medical treatment for this disease was ursodeoxycholic acid, which was approved in 1997 after it was shown to delay the progressi...
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Proteomics in Primary Biliary Cholangitis

2019
Primary biliary cholangitis is a chronic cholestatic liver disease characterized by the presence of serum antimitochondrial antibodies and immune-mediated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated.
You, Li, Ruqui, Tang, Patrick S C, Leung, M Eric, Gershwin, Xiong, Ma   +4 more
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Primary biliary cholangitis

Medicine, 2019
Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by lymphocytic destruction of the small, intrahepatic bile ducts, causing chronic cholestasis and progressive fibrosis that eventually leads to biliary cirrhosis.
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