Results 121 to 130 of about 7,020,631 (350)

Multimorbidity: Technical Series on Safer Primary Care [PDF]

, 2016
No abstract ...
Fischbacher-Smith, Denis, Furler, John, Mercer, Stewart, Moffat, Keith, Sanci, Lena   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Decision letter for "Effectiveness of physical activity prescription by primary care nurses using health assets: A randomized controlled trial"

, 2020

openalex   +1 more source

Incorporating Naloxone Education Into Routine Primary Care [PDF]

, 2018
Opioid overdoses are a growing public health concern in Vermont and nationwide. Naloxone can save the life of someone who overdoses, if those around them know how to use it.
Goldberg, Eli
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Primary care

Academic Medicine, 1976
G, Virella, H H, Fudenberg
openaire   +3 more sources

Effectiveness of a screening tool to assess prevention and rehabilitation needs of 45 to 59 years old in primary care – study protocol of a pragmatic randomized controlled trial (PReHa45) [PDF]

, 2023
Jennifer Marie Burchardi, K Spyra, Martin Brünger   +2 more
openalex   +1 more source

Promoting family medicine [PDF]

, 2007
The year 2002 saw the publication of a landmark white paper in the United Kingdom entitled "Shifting the balance." It proposed redistribution of funds with the lion's share of the NHS budget going towards Primary Care services.
Abela, Jurgen C.
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Evaluation of primary care mental health integration and screening of anxiety and depression symptoms in Qatar from 2018 to 2023

Scientific Reports
This study examines the development of the Primary Health Care Corporation’s (PHCC) mental health integration programs in Qatar, focusing on their impact on access to care and management of prevalent mental health conditions, and estimating their burden ...
Samya Ahmad Al Abdulla, Azza Mustafa Mohammed, Mariama Aminata Mansaray, Mohamed Ghaith Al-Kuwari   +3 more
doaj   +1 more source