Results 141 to 150 of about 11,388,967 (312)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Primary Care Reimbursement Service Statistical Analysis of Claims and Payments 2014

open access: yes, 2016
The Primary Care Reimbursement Service (PCRS) is responsible for reimbursing GPs, Dentists, Pharmacists, Optometrists/Ophthalmologists and other contractors who provide free or reduced-cost services to the public across a range of primary care schemes ...
Primary Care Reimbursement Service (PCRS)
core  

Implementing screening programmes in primary care versus a centralised administration: a qualitative study of atrial fibrillation screening

open access: yesBMC Primary Care
Background General practices have been tasked with increasing detection of atrial fibrillation (AF) to reduce stroke. Paroxysmal AF is often missed through usual care but can be detected through screening with repeated ECGs over a period of time using ...
Rakesh N Modi   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Primary Care Reimbursement Service Statistical Analysis of Claims and Payments 2015

open access: yes, 2016
The Primary Care Reimbursement Service (PCRS) is responsible for reimbursing GPs, Dentists, Pharmacists, Optometrists/Ophthalmologists and other contractors who provide free or reduced-cost services to the public across a range of primary care schemes ...
Primary Care Reimbursement Service (PCRS)
core  

Primary care division: operational plan 2014 [PDF]

open access: yes, 2013
The development of the Primary Care service is a key element of the overall Health Reform programme. The core objective is to achieve a more balanced health service by ensuring that the vast majority of patients and clients who require urgent or ...
Health Service Executive (HSE), Primary Care Division
core  

Health Professional Underserved Areas Report, Kansas, 2012. Primary care underserved areas report, Kansas, 2012.

open access: yes, 2013
INTRODUCTION -- Kansas PopulatiOn Density Peer Groups -- PART ONE: HEALTH CARE WORKFORCE SHORTAGE AREAS: Federal Primary Care HPSAs (Health Professional Shortage Areas); Federal Dental HPSAs (Health Professional Shortage Areas); Federal Mental Health ...
Kansas. Primary Care Office.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

The Power of Primary Care to Improve Health [PDF]

open access: yesFam Med
Sexton S   +6 more
europepmc   +2 more sources

Health Professional Underserved Areas Report, Kansas, 2014. Primary care underserved areas report, Kansas, 2014.

open access: yes, 2015
INTRODUCTION -- Kansas PopulatiOn Density Peer Groups -- PART ONE: HEALTH CARE WORKFORCE SHORTAGE AREAS: Federal Primary Care HPSAs (Health Professional Shortage Areas); Federal Dental HPSAs (Health Professional Shortage Areas); Federal Mental Health ...
Kansas. Primary Care Office.
core   +1 more source

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