Results 91 to 100 of about 5,628,138 (356)
Signaling in the primary cilium through the lens of the Hedgehog pathway
Wiley Interdisciplinary Reviews: Developmental Biology, 2020 Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile.
E. Gigante, T. Caspary
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Trafficking to the primary cilium membrane
Molecular Biology of the Cell, 2017 The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube, kidney, and brain. The primary cilium is the site where a subset of the cell's membrane proteins is enriched. However,
Mukhopadhyay, Saikat +5 more
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Building the primary cilium membrane [PDF]
Cilia, 2012 Ciliogenesis involves coordinated assembly of a microtubule-based axoneme from the mother centriole and vesicular membrane transport and fusion forming a ciliary membrane around the developing axoneme. We, and others have reported that a Rab11-Rab8 cascade functions in ciliogenesis.
Westlake, CJ +5 more
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Cell Reports, 2018 Summary: The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material.
Maren Mönnich +15 more
doaj +1 more source
Nature Communications, 2020 Cells subjected to stress situations mobilize specific membranes and proteins to initiate autophagy. Phosphatidylinositol-3-phosphate (PI3P), a crucial lipid in membrane dynamics, is known to be essential in this context.
Asma Boukhalfa +8 more
semanticscholar +1 more source
Isolation of Primary Cilia by Shear Force [PDF]
, 2013 The cell’s primary cilium is both a mechanical and chemical sensor involved in many signaling pathways. In order to ascertain protein enrichment in the primary cilium or study sub-ciliary localization of various proteins, it is advantageous to remove the
Mitchell, Kimberly A. P.
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Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources
Cell Stress, 2019 Autophagy is a conserved molecular pathway directly involved in the degradation and recycling of intracellular components. Autophagy is associated with a response to stress situations, such as nutrients deficit, chemical toxicity, mechanical stress or ...
Naïma Zemirli +5 more
doaj +1 more source
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]
, 2016 The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy +4 more
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Trafficking in and to the primary cilium [PDF]
Cilia, 2012 Abstract Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the ...
Hsiao, Yi-Chun +2 more
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