Results 91 to 100 of about 20,808 (274)

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish

BMC Biology, 2010
Background In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
van Eeden Freek, Richardson Joanna, Kim Hyejeong, Ingham Philip W   +3 more
doaj   +1 more source

Building the primary cilium membrane [PDF]

Cilia, 2012
Ciliogenesis involves coordinated assembly of a microtubule-based axoneme from the mother centriole and vesicular membrane transport and fusion forming a ciliary membrane around the developing axoneme. We, and others have reported that a Rab11-Rab8 cascade functions in ciliogenesis.
Westlake, CJ, Rahajeng, J, Lu, Q, Scheller, RH, Caplan, S, Jackson, PK   +5 more
openaire   +1 more source

The primary cilium orchestrates chondrocyte mechanotransduction

, 2012
Purpose: to understand the role of the chondrocyte primary cilium in mechanotransduction. The primary cilium is a singular organelle protruding outward from the mature centriole into the extracellular space, decorated with many receptors and integrins ...
Zuo, N., Haycraft, C.J., Poole, C.A., Knight, M.M., Wann, A.K., Jenson, C.G., McGlashan, S.R., et al.   +7 more
core   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Sensory Primary Cilium is a Distinct Signaling Compartment

, 2019
The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling ...
Sherpa, Rinzhin Tshering
core   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia

Scientific Reports, 2017
The morphogenic factor Sonic hedgehog (Shh) signals through the primary cilium, which relies on intraflagellar transport to maintain its structural integrity and function.
Jie Ding, Lei Shao, Yixing Yao, Xin Tong, Huaize Liu, Shen Yue, Lu Xie, Steven Y. Cheng   +7 more
doaj   +1 more source

The role of primary cilia in neuronal function

Neurobiology of Disease, 2010
The “ciliopathies” are a newly defined group of disorders characterized by defects in the structure or function of the cellular primary cilium. Patients with these disorders display variably expressive fibrocystic renal disease, retinal blindness ...
Jeong Ho Lee, Joseph G. Gleeson
doaj   +1 more source

Mechanosensation and the primary cilium

The FASEB Journal, 2008
The primary cilium has come under increased scrutiny as a site for mechano‐ and chemosensation by cells. We have undertaken a program of study using mouse renal cell lines from the cortical collecting duct and to quantify how mechanical forces arising from fluid shear transduce to a cellular response.
openaire   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source