Results 71 to 80 of about 5,628,138 (356)

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

Primary cilium and its role in tumorigenesis [PDF]

Journal of Zhejiang University (Medical Sciences), 2021
The primary cilium, a sensory organelle that protrudes from the surface of most eukaryotic cells, receives and transduces various critical signals that are essential for normal development and homeostasis. Structural or functional disruption of primary cilia causes a number of human diseases, including cancer.
Hongmei, Mao, Yi, Sun
openaire   +2 more sources

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

The primary cilium [PDF]

Organogenesis, 2014
The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and
Fry, Andrew M, Leaper, Michelle J, Bayliss, Richard   +2 more
openaire   +2 more sources

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar, Baker, Berbari, Boyault, Breunig, Caspary, Corbit, Cotto, Davenport, Fliegauf, Gherman, Han, Haycraft, Kültz, Lange, McGlashan, Meimaridou, Nauli, Ng, Nigg, Overgaard, Pedersen, Pugacheva, Quarmby, Rohatgi, Rosenbaum, Schneider, Seeley, Singla, Taipale, Takaki, Weis, Williams   +32 more
core   +1 more source

Role of Primary Cilia in Skeletal Disorders

Stem Cells International, 2022
Primary cilia are highly conserved microtubule-based organelles that project from the cell surface into the extracellular environment and play important roles in mechanosensation, mechanotransduction, polarity maintenance, and cell behaviors during organ
Xinhua Li, Song Guo, Yang Su, Jiawei Lu, Donghua Hang, Shao Cao, Qiang Fu, Ziqing Li   +7 more
doaj   +1 more source

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]

, 2015
Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista, A Onnis, AC Smith, AH Hutagalung, AL Kullas, AW van der Velden, BT Keady, C Cassioli, C Geisler, C Margadant, C T Baldari, C Wasmeier, CJ Westlake, CP Horgan, DA MacLeod, DS Gomez, E Schonteich, EM Manders, F Finetti, F Finetti, F Finetti, G Bonello, G Iezzi, G Patino-Lopez, GJ Pazour, H Soares, I Jordens, JA Follit, JC Stinchcombe, JK Chen, K Geddes, L Patrussi, L Patrussi, LB Pedersen, LI Ehrlich, M de la Roche, M Esquerré, M Gottardo, M Kurowska, MV Nachury, N Capitani, NB Martín-Cófreces, RS Kalupahana, S Pacini, S Spanò, S Spanò, S Spanò, S Wang, SR McGlashan, SY Wong, V Das, VM Wu   +51 more
core   +1 more source

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Nature Genetics, 2009
Monique Jacoby, James J. Cox, Stéphanie Gayral, Daniel J. Hampshire, Muhammad Ayub, Marianne Blockmans, Eileen Pernot, Marina V. Kisseleva, Philippe Compère, Serge N. Schiffmann, Fanni Gergely, John H Riley, David Pérez‐Morga, C. Geoffrey Woods, Stéphane Schurmans   +14 more
openalex   +4 more sources

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]

, 2015
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair, Bakeberg, Belzile, Bergman, Cao, Chacon-Heszele, Chih, Dentler, Dorn, Engel, Ferris, Firestone, Garcia-Gonzalo, Gerdes, Goetz, Goodenough, Goodenough, Hildebrandt, Hogan, Hu, Hunnicutt, Hunnicutt, Hyman, Kim, Kong, Kubo, Lancaster, Lin, Liu, Liu, Malicki, Meng, Milenkovic, Molla-Herman, Mukhopadhyay, Mukhopadhyay, Nachury, Ning, Ocbina, Pasquale, Pazour, Pazour, Pedersen, Pijst, Pijst, Rohatgi, Rohatgi, Rosenbaum, Sang, Shih, Snell, Snell, Snell, Tai, Wang, Wang, Wang, Weise, Wiese, Williams, Wilson, Wood, Wood, Ye   +63 more
core   +3 more sources

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length [PDF]

, 2018
Axonemal dyneins, including inner dynein arm I1, assemble in the cytoplasm prior to transport into cilia by intraflagellar transport (IFT). How I1 dynein interacts with IFT is not understood.
Alford, Lea M, Dutcher, Susan K, Fu, Gang, Gokhale, Avanti, Hunter, Emily L, Hwang, Juyeon, Kamiya, Ritsu, Lechtreck, Karl, Lewis, Brian, Lin, Huawen, Nicastro, Daniela, Sale, Winfield S, Wirschell, Maureen, Yamamoto, Ryosuke, Yang, Fan   +14 more
core   +2 more sources