Results 51 to 60 of about 5,628,138 (356)
Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]
PLoS ONE, 2012 CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou +5 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
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Ciliary control of adipocyte progenitor cell fate regulates energy storage
Frontiers in Cell and Developmental Biology, 2022 The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer +2 more
doaj +1 more source
Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
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Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
Frontiers in Endocrinology, 2022 The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos +7 more
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Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division [PDF]
Cell, 2013 Judith T.M.L. Paridaen +2 more
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Journal of Clinical Investigation, 2021 The melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis, and mutations in the MC4R are the most common cause of monogenic obesity.
Yi Wang +7 more
semanticscholar +1 more source
Development, 2021 The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types.
Emily K. Ho, T. Stearns
semanticscholar +1 more source
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
eLife, 2023 The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang +13 more
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Bone, 2021 The benefits of physical loading to skeletal mass is well known. The primary cilium has emerged as an important organelle in bone mechanobiology/mechanotransduction, particularly in mesenchymal stem/stromal cells, yet the molecular mechanisms of cilium ...
G. Johnson, S. Fair, D. Hoey
semanticscholar +1 more source