Results 51 to 60 of about 4,304,152 (140)

Factors That Influence Primary Cilium Length [PDF]

, 2011
Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies.
Miyazaki, Ikuko, Kasahara, Kyosuke, Asanuma, Masato, Miyoshi, Ko   +3 more
core   +1 more source

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration. [PDF]

Sci Adv
International audienceThe saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through GPR161.
Paillard T, Allam A, Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, Stoufflet J, Messaoudi S, Spassky N, Nédélec S, Dusart I, Trembleau A, Isabelle Caillé.   +12 more
europepmc   +2 more sources

DataSheet1_Dendritic cell proliferation by primary cilium in atopic dermatitis.pdf

, 2023
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Fumitaka Fujita (4164472), Fumihiro Okada (4164466), Ken J. Ishii (7298471), Hiroshi Itoh (40927), Manami Toriyama (15356836), Motoki Nakamura (7408199), Yukiko Atsumi (15356842), Michinori Toriyama (92443), Akimichi Morita (109962), Defri Rizaldy (15356839)   +9 more
core   +1 more source

DataSheet1_Dendritic cell proliferation by primary cilium in atopic dermatitis.docx

, 2023
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Fumitaka Fujita (4164472), Fumihiro Okada (4164466), Ken J. Ishii (7298471), Defri Rizaldy, Ken J. Ishii, Manami Toriyama (15356836), Michinori Toriyama, Michinori Toriyama (92443), Yukiko Atsumi, Hiroshi Itoh, Fumitaka Fujita, Motoki Nakamura, Defri Rizaldy (15356839), Hiroshi Itoh (40927), Fumihiro Okada, Motoki Nakamura (7408199), Yukiko Atsumi (15356842), Akimichi Morita, Akimichi Morita (109962), Manami Toriyama   +19 more
core   +1 more source

The primary cilium orchestrates chondrocyte mechanotransduction [PDF]

, 2012
Purpose: to understand the role of the chondrocyte primary cilium in mechanotransduction. The primary cilium is a singular organelle protruding outward from the mature centriole into the extracellular space, decorated with many receptors and integrins ...
Zuo, N., Haycraft, C.J., Poole, C.A., Knight, M.M., Wann, A.K., Jenson, C.G., McGlashan, S.R., et al.   +7 more
core   +1 more source

Sensory Primary Cilium is a Distinct Signaling Compartment [PDF]

, 2019
The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling ...
Sherpa, Rinzhin Tshering
core   +1 more source

Long-Pentraxin 3 Affects Primary Cilium in Zebrafish Embryo and Cancer Cells via the FGF System [PDF]

, 2020
Primary cilium drives the left-right asymmetry process during embryonic development. Moreover, its dysregulation contributes to cancer progression by affecting various signaling pathways.
Chiodelli, Paola
core   +3 more sources

Modeling the deformation of primary cilium

, 2011
In this thesis we developed a new mechanics model of the primary cilium and analyzed its bending behavior. The primary cilium that extends from the cell surface can detect the mechanical signals of the surrounding environment.
徐强, Xu, Qiang
core   +1 more source

Primary Cilium-Dependent Signaling Mechanisms [PDF]

, 2017
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment.
Nedaa Alomari, Alomari, Nedaa, Rajasekharreddy Pala, Nauli, Surya M., Surya Nauli, Pala, Rajasekharreddy   +5 more
core   +1 more source

Regulation of primary cilia formation by ceramide[S]

Journal of Lipid Research, 2009
The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the ...
Guanghu Wang, Kannan Krishnamurthy, Erhard Bieberich   +2 more
doaj   +1 more source