Results 31 to 40 of about 10,359,121 (234)

Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology

Communications Biology
The dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan, Ebru Topçu, Elif Nur Firat-Karalar   +2 more
doaj   +2 more sources

Neuronal guidance behaviours: the primary cilium perspective

Frontiers in Cell and Developmental Biology
The establishment of functional neuronal circuits critically relies on the ability of developing neurons to accurately sense and integrate a variety of guidance signals from their surrounding environment.
Melody Atkins, Coralie Fassier, Xavier Nicol   +2 more
doaj   +2 more sources

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development. [PDF]

PLoS ONE, 2017
Adenylate cyclase type III (AC3) is localized in plasma membrane of neuronal primary cilium and can be used as a marker of this cilium. AC3 has also been detected in some other primary cilia such as those of fibroblasts, synoviocytes or astrocytes ...
Maria Cristina Antal, Karelle Bénardais, Brigitte Samama, Cyril Auger, Valérie Schini-Kerth, Said Ghandour, Nelly Boehm   +6 more
doaj   +1 more source

Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Imbalance between neural cell proliferation and neuronal differentiation during development can result in pediatric cancer or neurodevelopmental disorders.
Sangwoo Shim, Raman Goyal, A. Panoutsopoulos, O. Balashova, David K. Lee, Laura N. Borodinsky   +5 more
semanticscholar   +1 more source

Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration

bioRxiv, 2023
Various mammalian cells have autonomous cellular clocks that are produced by the transcriptional cycle of clock genes. Cellular clocks provide circadian rhythms for cellular functions via transcriptional and cytoskeletal regulation.
Ryota Nakazato, Y. Matsuda, Faryal Ijaz, K. Ikegami   +3 more
semanticscholar   +1 more source

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]

PLoS ONE, 2012
CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou, Ying Zhang, Min Cheng, Jerome B Rattner, Ina Dobrinski, Frans A van der Hoorn   +5 more
doaj   +1 more source

Ciliary control of adipocyte progenitor cell fate regulates energy storage

Frontiers in Cell and Developmental Biology, 2022
The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer, Mark D. Lee, Keren I. Hilgendorf   +2 more
doaj   +1 more source

Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis

Molecular Medicine
Background Hyperglucagonemia is a hallmark of diabetes mellitus, resulting from the dysregulation of glucagon secretion by pancreatic alpha-cells. Although glucose sensing and insulin signaling are well-established regulatory processes, the pathways that
Elena Casanueva-Álvarez, Alba Sanz-González, Alicia Vilas, Patricia Cámara-Torres, Magalie A. Ravier, Sara Eslava-Alcon, M. Carmen Duran-Ruiz, Cristina M. Ramírez, Peristera-Ioanna Petropoulou, Teresa Rodriguez-Calvo, Beatriz Merino, Germán Perdomo, Irene Cozar-Castellano   +12 more
doaj   +2 more sources

The multifaceted roles of microtubule-associated proteins in the primary cilium and ciliopathies.

Journal of Cell Science, 2023
The primary cilium is a conserved microtubule-based organelle that is critical for transducing developmental, sensory and homeostatic signaling pathways.
J. Deretic, Ezgi Odabasi, E. N. Firat-Karalar   +2 more
semanticscholar   +1 more source

Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

Frontiers in Endocrinology, 2022
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos, Elena Casanueva-Álvarez, Carlos M. González-Casimiro, Beatriz Merino, Germán Perdomo, Irene Cózar-Castellano, Irene Cózar-Castellano, Irene Cózar-Castellano   +7 more
doaj   +1 more source