NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling [PDF]
Life Science AllianceResearchers discover that NME7, a lesser studied protein, is required for cilium assembly and Hedgehog signaling, impacting ciliary microtubule stability. This study advances our understanding of primary cilium assembly and functions.
Menghui Ji +7 more
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Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration [PDF]
Science Advances, 2020 The primary cilium regulates neuronal migration via cyclic AMP production activating protein kinase A at the centrosome. The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells.
Julie Stoufflet +9 more
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The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]
eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
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Cell Reports, 2018 Summary: Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype.
Helen Louise May-Simera +25 more
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High water intake induces primary cilium elongation in renal tubular cells [PDF]
Kidney Research and Clinical PracticeBackground The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong +5 more
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Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis [PDF]
Molecular MedicineBackground Hyperglucagonemia is a hallmark of diabetes mellitus, resulting from the dysregulation of glucagon secretion by pancreatic alpha-cells. Although glucose sensing and insulin signaling are well-established regulatory processes, the pathways that
Elena Casanueva-Álvarez +12 more
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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Cancer Cell, 2018 Human melanomas frequently harbor amplifications of EZH2. However, the contribution of EZH2 to melanoma formation has remained elusive. Taking advantage of murine melanoma models, we show that EZH2 drives tumorigenesis from benign BrafV600E- or NrasQ61K ...
D. Zingg +17 more
semanticscholar +3 more sources
Enteric neurons show a primary cilium [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractThe primary cilium is a non‐motile cilium whose structure is 9+0. It is involved in co‐ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies.
Mª José Luesma +5 more
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Primary cilium and TULP3-dependent ciliary targeting of ACE2 in SARS-CoV-2 tropism. [PDF]
Cell Commun SignalDu YH +12 more
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Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance A properly functioning primary cilium is prerequisite for both normal development and aging of all ciliated organisms, including humans. In vertebrates, the signaling of Hedgehog family morphogens depends entirely on primary cilium. Recently,
Michaela Kunova Bosakova +27 more
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