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The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Satir, Peter +2 more
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Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
Frontiers in Endocrinology, 2022 The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos +7 more
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Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration
Nature Communications, 2023 Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.
Melody Atkins +5 more
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CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
eLife, 2023 The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang +13 more
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BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Single-molecule imaging in the primary cilium. [PDF]
Methods Cell Biol, 2023 The primary cilium is an important signaling organelle critical for normal development and tissue homeostasis. Its small dimensions and complexity necessitate advanced imaging approaches to uncover the molecular mechanisms behind its function. Here, we outline how single-molecule fluorescence microscopy can be used for tracking molecular dynamics and ...
Weiss LE +8 more
europepmc +3 more sources
The primary cilium as a gatekeeper of FGFR2 function. [PDF]
J Cell BiolIn this issue, Nita et al. (https://doi.org/10.1083/jcb.202311030) show that the primary cilium regulates FGFR2 signalling through spatial compartmentalization, enabling selective downstream activation. Disruption of ciliary localization in disease-linked FGFR2 variants highlights the role of the cilium as a signalling gatekeeper in development and ...
Kaushik R, Ladher RK.
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Primary cilium and its role in tumorigenesis [PDF]
Journal of Zhejiang University (Medical Sciences), 2021 The primary cilium, a sensory organelle that protrudes from the surface of most eukaryotic cells, receives and transduces various critical signals that are essential for normal development and homeostasis. Structural or functional disruption of primary cilia causes a number of human diseases, including cancer.
Hongmei, Mao, Yi, Sun
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Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]
, 2013 BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK +7 more
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