Results 31 to 40 of about 4,304,152 (140)

Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

Frontiers in Endocrinology, 2022
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos, Elena Casanueva-Álvarez, Carlos M. González-Casimiro, Beatriz Merino, Germán Perdomo, Irene Cózar-Castellano, Irene Cózar-Castellano, Irene Cózar-Castellano   +7 more
doaj   +1 more source

The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts

BMC Molecular and Cell Biology, 2020
Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal, Ananga Ghosh, Hardik Gala, Ajoy Aloysius, Neha Vyas, Jyotsna Dhawan   +5 more
doaj   +1 more source

CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Nature Communications, 2023
Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.
Melody Atkins, Maud Wurmser, Michèle Darmon, Fiona Roche, Xavier Nicol, Christine Métin   +5 more
doaj   +1 more source

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

eLife, 2023
The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang, Zheyong Liang, Tan Tan, Miao Zhang, Yina Jiang, Yangyang Shang, Xiaoqian Gao, Shaoran Song, Ruiqi Wang, He Chen, Jie Liu, Juan Li, Yu Ren, Peijun Liu   +13 more
doaj   +1 more source

The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation

Stem Cell Research, 2020
The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration.
Mi Nam Lee, Ju Han Song, Sin-Hye Oh, Nguyen Thi Tham, Jung-Woo Kim, Jin-Woo Yang, Eung-Sam Kim, Jeong-Tae Koh   +7 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source

A Model for Primary Cilium Biogenesis by Polarized Epithelial Cells: Role of the Midbody Remnant and Associated Specialized Membranes

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are solitary, microtubule-based protrusions surrounded by a ciliary membrane equipped with selected receptors that orchestrate important signaling pathways that control cell growth, differentiation, development and homeostasis. Depending on
Leticia Labat-de-Hoz, Armando Rubio-Ramos, Javier Casares-Arias, Miguel Bernabé-Rubio, Isabel Correas, Isabel Correas, Miguel A. Alonso   +6 more
doaj   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Knight, M.M., A. K. T. Wann, Wann, A.K.T., Knight, MM, Wann, AKT, M. M. Knight   +5 more
core   +1 more source

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage [PDF]

, 2014
Primary cilia are slender, microtubule based structures found in the majority of cell types with one cilium per cell. In articular cartilage, primary cilia are required for chondrocyte mechanotransduction and the development of healthy tissue.
Ramaswamy, G, Ramaswamy, Girish, Irianto, J, Serra, Rosa, Knight, MM, Knight, Martin M., Serra, R, Irianto, Jerome   +7 more
core   +1 more source

Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]

, 2007
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne, Erich A. Nigg, Gassner, Oliver S., Gassner, O. S., Susanne Graser, Stierhof, Y. D., Lavoie, S. B., Stierhof, York-Dieter, Nigg, E. A., Sébastien B. Lavoie, Le Clech, M., Stefan Lamla, Graser, S., Nigg, Erich A., Lavoie, Sébastien B., York-Dieter Stierhof, Le Clech, Mikael, Oliver S. Gassner, Mikael Le Clech, Lamla, S., Lamla, Stefan   +20 more
core   +1 more source