Results 21 to 30 of about 4,304,152 (140)

Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection. [PDF]

PLoS Pathogens
Chlamydia trachomatis is a clinically important bacterium that infects epithelial cells of the genitourinary and respiratory tracts and the eye. These differentiated cells are in a quiescent growth state and have a surface organelle called a primary ...
Roseleen Ekka, Abraham Gutierrez, Kirsten A Johnson, Ming Tan, Christine Sütterlin   +4 more
doaj   +2 more sources

The Primary Cilium as a Biomarker in the Hypoxic Adaptation of Bone Marrow-Derived Mesenchymal Stromal Cells: A Role for the Secreted Frizzled-Related Proteins

Biomarker Insights, 2011
A pivotal role in guiding mesenchymal stem cell (MSC) differentiation has recently been attributed to the primary cilium. This solitary, non-motile microtubule-based organelle emerging from the cell surface acts as a sensorial membrane structure ...
Sébastien Proulx-Bonneau, Borhane Annabi   +1 more
doaj   +2 more sources

Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis [PDF]

Molecular Medicine
Background Hyperglucagonemia is a hallmark of diabetes mellitus, resulting from the dysregulation of glucagon secretion by pancreatic alpha-cells. Although glucose sensing and insulin signaling are well-established regulatory processes, the pathways that
Elena Casanueva-Álvarez, Alba Sanz-González, Alicia Vilas, Patricia Cámara-Torres, Magalie A. Ravier, Sara Eslava-Alcon, M. Carmen Duran-Ruiz, Cristina M. Ramírez, Peristera-Ioanna Petropoulou, Teresa Rodriguez-Calvo, Beatriz Merino, Germán Perdomo, Irene Cozar-Castellano   +12 more
doaj   +2 more sources

The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium [PDF]

Communications Biology
The efficient transport of proteins into the primary cilium is a crucial step for many signaling pathways. Dysfunction of this process can lead to the disruption of signaling cascades or cilium assembly, resulting in developmental disorders and cancer ...
S. M. Niedziółka, S. Datta, T. Uśpieński, B. Baran, W. Skarżyńska, E. W. Humke, R. Rohatgi, P. Niewiadomski   +7 more
doaj   +2 more sources

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +4 more sources

Dendritic cell proliferation by primary cilium in atopic dermatitis

Frontiers in Molecular Biosciences, 2023
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama, Manami Toriyama, Manami Toriyama, Defri Rizaldy, Defri Rizaldy, Defri Rizaldy, Motoki Nakamura, Motoki Nakamura, Yukiko Atsumi, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumitaka Fujita, Fumitaka Fujita, Fumihiro Okada, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii, Ken J. Ishii   +19 more
doaj   +1 more source

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development. [PDF]

PLoS ONE, 2017
Adenylate cyclase type III (AC3) is localized in plasma membrane of neuronal primary cilium and can be used as a marker of this cilium. AC3 has also been detected in some other primary cilia such as those of fibroblasts, synoviocytes or astrocytes ...
Maria Cristina Antal, Karelle Bénardais, Brigitte Samama, Cyril Auger, Valérie Schini-Kerth, Said Ghandour, Nelly Boehm   +6 more
doaj   +1 more source

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]

PLoS ONE, 2012
CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou, Ying Zhang, Min Cheng, Jerome B Rattner, Ina Dobrinski, Frans A van der Hoorn   +5 more
doaj   +1 more source

Ciliary control of adipocyte progenitor cell fate regulates energy storage

Frontiers in Cell and Developmental Biology, 2022
The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer, Mark D. Lee, Keren I. Hilgendorf   +2 more
doaj   +1 more source

Primary cilium-mediated mechanotransduction in cartilage chondrocytes. [PDF]

Exp Biol Med (Maywood), 2023
Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment.
Zhang Y, Tawiah GK, Wu X, Zhang Y, Wang X, Wei X, Qiao X, Zhang Q.   +7 more
europepmc   +2 more sources