Results 21 to 30 of about 20,808 (274)
Synchronizing Protein Traffic to the Primary Cilium [PDF]
Frontiers in Genetics, 2019 The primary cilium is able to maintain a specific protein composition, which is critical for its function as a signaling organelle. Here we introduce a system to synchronize biosynthetic trafficking of ciliary proteins that is based on conditional aggregation domains (CADs).
Wladislaw Stroukov +10 more
core +6 more sources
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium [PDF]
Communications BiologyThe efficient transport of proteins into the primary cilium is a crucial step for many signaling pathways. Dysfunction of this process can lead to the disruption of signaling cascades or cilium assembly, resulting in developmental disorders and cancer ...
S. M. Niedziółka +7 more
doaj +2 more sources
Modeling the deformation of primary cilium
, 2015 In this thesis we developed a new mechanics model of the primary cilium and analyzed its bending behavior. The primary cilium that extends from the cell surface can detect the mechanical signals of the surrounding environment. Moreover, through its deflection and bending angle, the primary cilium can communicate with the cell regarding the ...
徐强, Xu, Qiang
openaire +3 more sources
Primary Cilium in CO25 Cell Line
, 2003 A few variety of cell type contain a primary cilium. Also the biological function(s) of primary cilia within such cell types are largely unknown. CO25 myoblast cell lines were cultured then they were stained with anti Glu- and Tyr- tubulin in this study. Glu-tubulin rich microtubules were only rarely seen in the cells.
Zeytinoğlu, Melih, Ocak, HY
openaire +3 more sources
The nociceptor primary cilium. [PDF]
BrainAbstract The primary cilium, a single microtubule-based organelle protruding from the surface of cells, utilizes intraflagellar transport (IFT) to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signaling pathways identified by expression of ...
Ganter GK +5 more
europepmc +3 more sources
Primary cilium-mediated mechanotransduction in cartilage chondrocytes. [PDF]
Exp Biol Med (Maywood), 2023 Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment.
Zhang Y +7 more
europepmc +2 more sources
Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development. [PDF]
PLoS ONE, 2017 Adenylate cyclase type III (AC3) is localized in plasma membrane of neuronal primary cilium and can be used as a marker of this cilium. AC3 has also been detected in some other primary cilia such as those of fibroblasts, synoviocytes or astrocytes ...
Maria Cristina Antal +6 more
doaj +1 more source
Trafficking in and to the primary cilium [PDF]
Cilia, 2012 Abstract Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the ...
Hsiao, Yi-Chun +2 more
openaire +2 more sources
The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
openaire +2 more sources
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Frontiers in Cell and Developmental Biology, 2022 The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer +2 more
doaj +1 more source