The primary cilium: a signalling centre during vertebrate development
Nature Reviews Genetics, 2010 Sarah C. Goetz, Kathryn V. Anderson
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Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation [PDF]
Journal of Neuroscience, 2021 Sonic hedgehog (Shh) signaling from the primary cilium drives cerebellar granule cell precursor (GCP) proliferation. Mutations of hedgehog (Hh) pathway repressors commonly cause medulloblastoma, the most prevalent and malignant childhood brain tumor that
Catherine Hong Huan Hor +4 more
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Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
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Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration. [PDF]
EMBO Rep, 2023 Various mammalian cells have autonomous cellular clocks that are produced by the transcriptional cycle of clock genes. Cellular clocks provide circadian rhythms for cellular functions via transcriptional and cytoskeletal regulation.
Nakazato R +3 more
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The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts [PDF]
BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Frontiers in Cell and Developmental Biology, 2021 Primary cilia are solitary, microtubule-based protrusions surrounded by a ciliary membrane equipped with selected receptors that orchestrate important signaling pathways that control cell growth, differentiation, development and homeostasis. Depending on
Leticia Labat-de-Hoz +6 more
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Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
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The nociceptor primary cilium. [PDF]
BrainThe primary cilium, a single microtubule-based organelle protruding from the surface of cells, utilizes intraflagellar transport (IFT) to establish and maintain its structure and function.
Ganter GK +5 more
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Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms [PDF]
npj MicrogravityBone density loss is a major concern for astronauts in space, largely due to altered mechanical stimuli in microgravity. These changes are thought to impact bone cells by directly affecting musculoskeletal cell physiology and disrupting mechanosensing ...
Domiziano D. Tosi +7 more
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Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology [PDF]
Communications BiologyThe dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan +2 more
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