Results 11 to 20 of about 20,808 (274)
The Primary Cilium as a Novel Extracellular Sensor in Bone [PDF]
Frontiers in Endocrinology, 2012 Mechanically induced adaptation of bone is required to maintain a healthy skeleton and defects in this process can lead to dramatic changes in bone mass, resulting in bone diseases such as osteoporosis.
David A Hoey +2 more
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Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model
Cells, 2023 The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN ...
Jie L. Tian +5 more
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Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]
PLoS ONE, 2012 CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou +5 more
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Primary Cilium-Dependent Signaling Mechanisms [PDF]
International Journal of Molecular Sciences, 2017 Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell.
Pala, Rajasekharreddy +2 more
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The Primary Cilium and Neuronal Migration
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons.
Julie Stoufflet, Isabelle Caillé
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The Primary Cilium as a Complex Signaling Center [PDF]
Current Biology, 2009 Respect for the primary cilium has undergone a remarkable renaissance over the past decade, and it is now thought to be an essential regulator of numerous signaling pathways. The primary cilium's functions range from the movement of cells and fluid, to sensory inputs involved with olfaction and photoreception.
Berbari, Nicolas F. +3 more
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Factors that influence primary cilium length.
Acta medica Okayama, 2011 Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter ...
Miyoshi, Ko +3 more
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Biomarker Insights, 2011 A pivotal role in guiding mesenchymal stem cell (MSC) differentiation has recently been attributed to the primary cilium. This solitary, non-motile microtubule-based organelle emerging from the cell surface acts as a sensorial membrane structure ...
Sébastien Proulx-Bonneau +1 more
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Dynamics of the Primary Cilium in Shear Flow [PDF]
Biophysical Journal, 2012 In this work, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both theoretical modeling and experiment. The cilium is modeled as an elastic beam that may undergo large deflection due to the hydrodynamic load. Equilibrium results show that the anchoring effects of the basal body on the cilium axoneme behave as
Young, Y.-N., Downs, M., Jacobs, C.R.
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Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis [PDF]
Molecular MedicineBackground Hyperglucagonemia is a hallmark of diabetes mellitus, resulting from the dysregulation of glucagon secretion by pancreatic alpha-cells. Although glucose sensing and insulin signaling are well-established regulatory processes, the pathways that
Elena Casanueva-Álvarez +12 more
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