Results 11 to 20 of about 10,359,121 (234)
Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model
Cells, 2023 The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN ...
Jie L. Tian +5 more
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Primary cilium and glioblastoma
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
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Compartmentalised cAMP signalling in the primary cilium [PDF]
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
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Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway +2 more
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Primary Cilium in Cancer Hallmarks
International Journal of Molecular Sciences, 2019 The primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of more than fifty years of research that has dramatically changed our ...
Nathalie Mazure +2 more
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Cell Reports, 2018 Summary: Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype.
Helen Louise May-Simera +25 more
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Dendritic cell proliferation by primary cilium in atopic dermatitis
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration
Nature Communications, 2023 Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.
Melody Atkins +5 more
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Primary cilium–mediated mechanotransduction in cartilage chondrocytes
Experimental biology and medicine, 2023 Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment.
Yang Zhang +7 more
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Frontiers in Cell and Developmental Biology, 2021 Primary cilia are solitary, microtubule-based protrusions surrounded by a ciliary membrane equipped with selected receptors that orchestrate important signaling pathways that control cell growth, differentiation, development and homeostasis. Depending on
Leticia Labat-de-Hoz +6 more
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