Results 11 to 20 of about 5,628,138 (356)
Compartmentalised cAMP signalling in the primary cilium [PDF]
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
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Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway +2 more
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The Primary Cilium and Neuronal Migration [PDF]
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons.
Julie Stoufflet, Isabelle Caillé
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Dendritic cell proliferation by primary cilium in atopic dermatitis [PDF]
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration [PDF]
Nature Communications, 2023 Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.
Melody Atkins +5 more
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Primary cilium-mediated mechanotransduction in cartilage chondrocytes. [PDF]
Exp Biol Med (Maywood), 2023 Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment.
Zhang Y +7 more
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The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium [PDF]
Communications Biology, 2021 The efficient transport of proteins into the primary cilium is a crucial step for many signaling pathways. Dysfunction of this process can lead to the disruption of signaling cascades or cilium assembly, resulting in developmental disorders and cancer ...
S. M. Niedziółka +7 more
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Primary cilium in kidney development, function and disease. [PDF]
Front Endocrinol (Lausanne), 2022 The primary cilium is a hair-like, microtubule-based organelle that is covered by the cell membrane and extends from the surface of most vertebrate cells.
Bai Y +6 more
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Neuronal guidance behaviours: the primary cilium perspective [PDF]
Frontiers in Cell and Developmental BiologyThe establishment of functional neuronal circuits critically relies on the ability of developing neurons to accurately sense and integrate a variety of guidance signals from their surrounding environment.
Melody Atkins +2 more
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Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
PLoS Biology, 2019 The primary cilium is a central signaling hub in cell proliferation and differentiation and is built and disassembled every cell cycle in many animal cells.
Mary Mirvis +3 more
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