Results 11 to 20 of about 4,304,152 (140)
Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway +2 more
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Compartmentalised cAMP signalling in the primary cilium [PDF]
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
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Neuronal guidance behaviours: the primary cilium perspective [PDF]
Frontiers in Cell and Developmental BiologyThe establishment of functional neuronal circuits critically relies on the ability of developing neurons to accurately sense and integrate a variety of guidance signals from their surrounding environment.
Melody Atkins +2 more
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The Primary Cilium as a Novel Extracellular Sensor in Bone [PDF]
Frontiers in Endocrinology, 2012 Mechanically induced adaptation of bone is required to maintain a healthy skeleton and defects in this process can lead to dramatic changes in bone mass, resulting in bone diseases such as osteoporosis.
David A Hoey +2 more
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Primary cilium and glioblastoma
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
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Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model
Cells, 2023 The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN ...
Jie L. Tian +5 more
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Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology [PDF]
Communications BiologyThe dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan +2 more
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Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms [PDF]
npj MicrogravityBone density loss is a major concern for astronauts in space, largely due to altered mechanical stimuli in microgravity. These changes are thought to impact bone cells by directly affecting musculoskeletal cell physiology and disrupting mechanosensing ...
Domiziano D. Tosi +7 more
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NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling [PDF]
Life Science AllianceResearchers discover that NME7, a lesser studied protein, is required for cilium assembly and Hedgehog signaling, impacting ciliary microtubule stability. This study advances our understanding of primary cilium assembly and functions.
Menghui Ji +7 more
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The Primary Cilium and Neuronal Migration
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons.
Julie Stoufflet, Isabelle Caillé
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