Results 41 to 50 of about 10,359,121 (234)
Journal of Cell Science, 2023 The primary cilium is a microtubule-based organelle that serves as a hub for many signaling pathways. It functions as part of the centrosome/cilium complex, which also contains the basal body and the centriolar satellites.
Ezgi Odabasi +6 more
semanticscholar +1 more source
Role of lipids in the control of autophagy and primary cilium signaling in neurons
Neural Regeneration Research, 2023 The brain is, after the adipose tissue, the organ with the greatest amount of lipids and diversity in their composition in the human body. In neurons, lipids are involved in signaling pathways controlling autophagy, a lysosome-dependent catabolic process
M. P. Hernández-Cáceres +7 more
semanticscholar +1 more source
BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
doaj +1 more source
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
eLife, 2023 The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang +13 more
doaj +1 more source
Journal of Clinical Investigation, 2021 The melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis, and mutations in the MC4R are the most common cause of monogenic obesity.
Yi Wang +7 more
semanticscholar +1 more source
Development, 2021 The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types.
Emily K. Ho, T. Stearns
semanticscholar +1 more source
Primary cilium in kidney development, function and disease
Frontiers in Endocrinology, 2022 The primary cilium is a hair-like, microtubule-based organelle that is covered by the cell membrane and extends from the surface of most vertebrate cells.
Yun-Feng Bai +6 more
semanticscholar +1 more source
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]
, 2013 BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK +7 more
core +1 more source
Recent advances in understanding assembly of the primary cilium membrane
Faculty Reviews, 2021 Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short
Saurabh Shakya, Christopher J. Westlake
semanticscholar +1 more source
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]
, 2012 Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Knight, M.M. +5 more
core +1 more source