Results 41 to 50 of about 4,304,152 (140)
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Ashworth, R +7 more
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Role of Primary Cilia in Skeletal Disorders
Stem Cells International, 2022 Primary cilia are highly conserved microtubule-based organelles that project from the cell surface into the extracellular environment and play important roles in mechanosensation, mechanotransduction, polarity maintenance, and cell behaviors during organ
Xinhua Li +7 more
doaj +1 more source
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]
, 2015 Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Thorpe, SD +4 more
core +1 more source
A Ciliary View of the Immunological Synapse
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
doaj +1 more source
Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
doaj +1 more source
Primary Cilia: The New Face of Craniofacial Research
Biomolecules, 2022 The primary cilium is a solitary, sensory organelle that extends from the surface of nearly every vertebrate cell, including craniofacial cells. This organelle converts chemical and physical external stimuli into intracellular signaling cascades and ...
Emily R. Moore
doaj +1 more source
Location of Smoothened Protein in Primary Cilium
, 2023 The primary cilium is an important organelle that facilitates numerous signaling pathways and delivers extracellular signals into the cell. Among those pathways is the Hedgehog (HH) signaling pathway, which has an important role in bone formation ...
Íris Ósk Halldórsdóttir 1999-
core +2 more sources
High water intake induces primary cilium elongation in renal tubular cells [PDF]
Kidney Research and Clinical PracticeBackground The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong +5 more
doaj +1 more source
A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. [PDF]
PLoS ONE, 2014 Primary cilia are specialized, acetylated microtubule-based signaling processes. Cilium assembly is activated by cellular quiescence and requires reconfiguration of microtubules, the actin cytoskeleton, and vesicular trafficking machinery.
Yanhua Rao +3 more
doaj +1 more source
Cell Reports, 2018 Summary: The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material.
Maren Mönnich +15 more
doaj +1 more source