Results 61 to 70 of about 4,304,152 (140)
Dynamics of the Primary Cilium in Shear Flow [PDF]
, 2012 In this work, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both theoretical modeling and experiment. The cilium is modeled as an elastic beam that may undergo large deflection due to the hydrodynamic load ...
Jacobs, C.R., Downs, M., Young, Y.-N.
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eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
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BMC Biology, 2010 Background In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
van Eeden Freek +3 more
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A Mechanism of Mechanotransduction Mediated by the Primary Cilium [PDF]
, 2014 Mechanotransduction is a process by which cells sense and convert mechanical loads into biochemical signals and transcriptional changes. This process is particularly critical in bone, a metabolically active tissue that continously remodels and adapts to ...
Lee, Kristen Lauren
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The role of primary cilia in neuronal function
Neurobiology of Disease, 2010 The “ciliopathies” are a newly defined group of disorders characterized by defects in the structure or function of the cellular primary cilium. Patients with these disorders display variably expressive fibrocystic renal disease, retinal blindness ...
Jeong Ho Lee, Joseph G. Gleeson
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Autophagy alteration prevents primary cilium disassembly in RPE1 cells
, 2018 Primary cilium is a microtubule structure that emanates from the surface of most human cells. Primary cilia assemble during the resting stage (Go phase) and disassemble with cell cycle progression.
Maharjan, Yunash +15 more
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Scientific Reports, 2017 The morphogenic factor Sonic hedgehog (Shh) signals through the primary cilium, which relies on intraflagellar transport to maintain its structural integrity and function.
Jie Ding +7 more
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BMC Cell Biology, 2008 Background Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia.
Wang Weiping, Brautigan David L
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Exploring the Spectrum of Kidney Ciliopathies
Diagnostics, 2020 Ciliopathies are a group of multi-organ diseases caused by the disruption of the primary cilium. This event leads to a variety of kidney disorders, including nephronophthisis, renal cystic dysplasia, and renal cell carcinoma (RCC).
Matteo Santoni +7 more
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The Primary Cilium: Keeper of the Key to Cell Division [PDF]
, 2007 Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al.
Pan, Junmin, Snell, William
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