Results 61 to 70 of about 5,628,138 (356)
Primary Cilium-Dependent Signaling Mechanisms [PDF]
International Journal of Molecular Sciences, 2017 Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell.
Pala, Rajasekharreddy +2 more
openaire +3 more sources
Stem Cell Research, 2020 The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration.
Mi Nam Lee +7 more
doaj +1 more source
Recent advances in understanding assembly of the primary cilium membrane
Faculty Reviews, 2021 Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short
Saurabh Shakya, Christopher J Westlake
semanticscholar +1 more source
The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling
bioRxiv, 2021 The primary cilium is an organelle present in most adult mammalian cells and is thought of as an antenna for detection of a variety of signals. Here we use intact mouse pancreatic islets of Langerhans to investigate signalling properties of the primary ...
Gonzalo Sanchez +10 more
semanticscholar +1 more source
Single-molecule imaging in the primary cilium. [PDF]
Methods Cell Biol, 2023 The primary cilium is an important signaling organelle critical for normal development and tissue homeostasis. Its small dimensions and complexity necessitate advanced imaging approaches to uncover the molecular mechanisms behind its function. Here, we outline how single-molecule fluorescence microscopy can be used for tracking molecular dynamics and ...
Weiss LE +8 more
europepmc +3 more sources
The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP. [PDF]
DevelopmentSharma R +8 more
europepmc +2 more sources
Hypothalamic primary cilium: A hub for metabolic homeostasis
Experimental and Molecular Medicine, 2021 Obesity is a global health problem that is associated with adverse consequences such as the development of metabolic disorders, including cardiovascular disease, neurodegenerative disorders, and type 2 diabetes.
D. Yang, Jessica K Hong, Ki Woo Kim
semanticscholar +1 more source
The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Satir, Peter +2 more
openaire +3 more sources
Degrading proteins at the primary cilium [PDF]
Nature Reviews Molecular Cell Biology, 2015 openaire +3 more sources
Cells, 2021 Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance.
Sila Yanardag, E. Pugacheva
semanticscholar +1 more source