Results 1 to 10 of about 4,304,152 (140)

The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flow

Cell Stress, 2019
Autophagy is a conserved molecular pathway directly involved in the degradation and recycling of intracellular components. Autophagy is associated with a response to stress situations, such as nutrients deficit, chemical toxicity, mechanical stress or ...
Naïma Zemirli, Asma Boukhalfa, Nicolas Dupont, Joëlle Botti, Patrice Codogno, Etienne Morel   +5 more
doaj   +1 more source

Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation

Frontiers in Cell and Developmental Biology, 2022
Primary cilia are microtubule-based, non-motile sensory organelles present in most types of growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit external signals to the cells in order to control growth, differentiation ...
Emanuela Senatore, Rosa Iannucci, Francesco Chiuso, Rossella Delle Donne, Laura Rinaldi, Antonio Feliciello   +5 more
doaj   +1 more source

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

Cell Reports, 2018
Summary: Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype.
Helen Louise May-Simera, Qin Wan, Balendu Shekhar Jha, Juliet Hartford, Vladimir Khristov, Roba Dejene, Justin Chang, Sarita Patnaik, Quanlong Lu, Poulomi Banerjee, Jason Silver, Christine Insinna-Kettenhofen, Dishita Patel, Mostafa Lotfi, May Malicdan, Nathan Hotaling, Arvydas Maminishkis, Rupa Sridharan, Brian Brooks, Kiyoharu Miyagishima, Meral Gunay-Aygun, Rajarshi Pal, Christopher Westlake, Sheldon Miller, Ruchi Sharma, Kapil Bharti   +25 more
doaj   +1 more source

The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro

Cells, 2020
Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi, Annie Ladoux, Sophie Giorgetti-Peraldi, Christian Dani   +3 more
doaj   +1 more source

NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.

PLoS ONE, 2019
Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius, Daisuke Takao, Kristen J Verhey   +2 more
doaj   +1 more source

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex

Cells, 2020
The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan, Dila Gulensoy, Elif Nur Firat-Karalar   +2 more
doaj   +1 more source

Transmission Electron Microscopy Tilt-Series Data from In-Situ Chondrocyte Primary Cilia

Data, 2021
The primary cilium has recently become the focus of intensive investigations into understanding the physical structure and processes of eukaryotic cells.
Michael J. Jennings, Timothy C. A. Molteno, Robert J. Walker, Jennifer J. Bedford, John P. Leader, Tony Poole   +5 more
doaj   +1 more source

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

Cell Reports, 2013
Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis.
Christian Alexandro Clement, Katrine Dalsgaard Ajbro, Karen Koefoed, Maj Linea Vestergaard, Iben Rønn Veland, Maria Perestrello Ramos Henriques de Jesus, Lotte Bang Pedersen, Alexandre Benmerah, Claus Yding Andersen, Lars Allan Larsen, Søren Tvorup Christensen   +10 more
doaj   +1 more source

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

Nature Communications, 2016
The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the
Qingwen Xu, Yuxia Zhang, Qing Wei, Yan Huang, Jinghua Hu, Kun Ling   +5 more
doaj   +1 more source

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]

PLoS ONE, 2009
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson, Miao-Hsueh Chen, Pao-Tien Chuang   +2 more
doaj   +1 more source