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Primary Cilium in Cancer Hallmarks
International Journal of Molecular Sciences, 2019 The primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of more than fifty years of research that has dramatically changed our ...
Lucilla Fabbri, F. Bost, N. Mazure
semanticscholar +6 more sources
A boundary element regularised Stokeslet method applied to cilia and flagella-driven flow [PDF]
, 2009 A boundary element implementation of the regularised Stokeslet method of Cortez is applied to cilia and flagella-driven flows in biology. Previously-published approaches implicitly combine the force discretisation and the numerical quadrature used to ...
Burgers J. M., Gray J., Sanderson M. J.
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Nature Communications, 2016 The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the
Qingwen Xu +5 more
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TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
Cell Reports, 2013 Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis.
Christian Alexandro Clement +10 more
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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
PLoS ONE, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson +2 more
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Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]
, 2006 The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
Evans, James E. +6 more
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Regulation of primary cilia formation by ceramide[S]
Journal of Lipid Research, 2009 The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the ...
Guanghu Wang +2 more
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Factors That Influence Primary Cilium Length [PDF]
, 2011 Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies.
Asanuma, Masato +3 more
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The primary cilium: its role as a tumor suppressor organelle.
Biochemical Pharmacology, 2020 The primary cilium is an organelle which nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna.
E. Peixoto +4 more
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Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy [PDF]
, 2014 Exome sequencing revealed a homozygous missense mutation (c.317C>G [p.Arg106Pro]) in POC1B, encoding POC1 centriolar protein B, in three siblings with autosomal-recessive cone dystrophy or cone-rod dystrophy and compound-heterozygous POC1B mutations (c ...
Arts, Heleen H +17 more
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