Results 1 to 10 of about 20,808 (274)
Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
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Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway +2 more
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Compartmentalised cAMP signalling in the primary cilium [PDF]
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
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Neuronal guidance behaviours: the primary cilium perspective [PDF]
Frontiers in Cell and Developmental BiologyThe establishment of functional neuronal circuits critically relies on the ability of developing neurons to accurately sense and integrate a variety of guidance signals from their surrounding environment.
Melody Atkins +2 more
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Dendritic cell proliferation by primary cilium in atopic dermatitis [PDF]
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
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Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology [PDF]
Communications BiologyThe dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan +2 more
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Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms [PDF]
npj MicrogravityBone density loss is a major concern for astronauts in space, largely due to altered mechanical stimuli in microgravity. These changes are thought to impact bone cells by directly affecting musculoskeletal cell physiology and disrupting mechanosensing ...
Domiziano D. Tosi +7 more
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Stem Cell Research, 2020 The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration.
Mi Nam Lee +7 more
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NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling [PDF]
Life Science AllianceResearchers discover that NME7, a lesser studied protein, is required for cilium assembly and Hedgehog signaling, impacting ciliary microtubule stability. This study advances our understanding of primary cilium assembly and functions.
Menghui Ji +7 more
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High water intake induces primary cilium elongation in renal tubular cells [PDF]
Kidney Research and Clinical PracticeBackground The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong +5 more
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