Results 1 to 10 of about 10,359,121 (234)
Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation
Frontiers in Cell and Developmental Biology, 2022 Primary cilia are microtubule-based, non-motile sensory organelles present in most types of growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit external signals to the cells in order to control growth, differentiation ...
Emanuela Senatore +5 more
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Signalling in the primary cilium through the lens of the Hedgehog pathway
Wiley Interdisciplinary Reviews: Developmental Biology, 2020 Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile.
E. Gigante, T. Caspary
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NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.
PLoS ONE, 2019 Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius +2 more
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Nature Communications, 2020 Cells subjected to stress situations mobilize specific membranes and proteins to initiate autophagy. Phosphatidylinositol-3-phosphate (PI3P), a crucial lipid in membrane dynamics, is known to be essential in this context.
Asma Boukhalfa +8 more
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TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
Cell Reports, 2013 Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis.
Christian Alexandro Clement +10 more
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Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration
Science Advances, 2020 The primary cilium regulates neuronal migration via cyclic AMP production activating protein kinase A at the centrosome. The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells.
J. Stoufflet +9 more
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A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex
Cells, 2020 The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan +2 more
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Bone Research, 2020 Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets.
A. Suzuki +6 more
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Nature Communications, 2016 The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the
Qingwen Xu +5 more
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Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Cells, 2020 Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner +4 more
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