Results 121 to 130 of about 4,814,966 (373)
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
bioRxiv, 2020 Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body.
J. N. Hansen +10 more
semanticscholar +1 more source
Fluid transport at low Reynolds number with magnetically actuated artificial cilia [PDF]
, 2008 By numerical modeling we investigate fluid transport in low-Reynolds-number flow achieved with a special elastic filament or artifical cilium attached to a planar surface. The filament is made of superparamagnetic particles linked together by DNA double strands.
arxiv +1 more source
Organogenesis, 2014 The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and
Andrew M. Fry +2 more
openaire +3 more sources
Advanced Materials Technologies, EarlyView.This study proposes a magnetoelastic strain sensor for highly deformed posture perception. The sensor can maintain stable sensing signal output under significant strain (200%) and at varying stretch rates (ranging from 1000 to 8000 mm min−1). The sensor design is simple and can be applied to soft robots and wearable devices.
Jing Shu +12 more
wiley +1 more source
Nature Communications, 2016 The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the
Qingwen Xu +5 more
doaj +1 more source
Metachronal motion of artificial magnetic cilia [PDF]
Soft Matter, 2018,14, 3689-3693, 2018 Organisms use hair-like cilia that beat in a metachronal fashion to actively transport fluid and suspended particles. Metachronal motion emerges due to a phase difference between beating cycles of neighboring cilia and appears as traveling waves propagating along ciliary carpet.
arxiv +1 more source
Primary Cilia Dynamics, Morphology and Acetylation are Abnormal in Huntington’s Disease Cell Models [PDF]
, 2015 The primary cilium is a singular signaling organelle found on most mammalian cell types. Dysfunction of the primary cilium or associated structures form a group of genetic disorders called ciliopathies.
Woloshansky, Tanya S.
core
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]
, 2016 The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy +4 more
core +1 more source
Chapter 9 The Primary Cilium [PDF]
, 2008 Cilia function as critical sensors of extracellular information, and ciliary dysfunction underlies diverse human disorders including situs inversus, polycystic kidney disease, retinal degeneration, and Bardet-Biedl syndrome. Importantly, mammalian primary cilia have recently been shown to mediate transduction of Hedgehog (Hh) signals, which are ...
Sunny Y. Wong, Jeremy F. Reiter
openaire +3 more sources
The Role of the Primary Cilium in Sensing Extracellular pH [PDF]
Cells, 2019 Biosensors on the membrane of the vascular endothelium are responsible for sensing mechanical and chemical signals in the blood. Transduction of these stimuli into intracellular signaling cascades regulate cellular processes including ion transport, gene expression, cell proliferation, and/or cell death.
Atkinson, Kimberly F. +2 more
openaire +4 more sources