Results 141 to 150 of about 5,628,138 (356)
Polycystin-2 Is Required for Chondrocyte Mechanotransduction and Traffics to the Primary Cilium in Response to Mechanical Stimulation [PDF]
, 2021 Clare L. Thompson +4 more
openalex +1 more source
eLife, 2018 Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels.
Xiaowen Liu +5 more
semanticscholar +1 more source
Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer
Journal of Cellular Physiology, 2020 The primary cilium is an antennae‐like structure extent outside the cell surface. It has an important role in regulating cell‐signaling transduction to affect proliferation, differentiation and migration.
Bo Wang, Zheyong Liang, Peijun Liu
semanticscholar +1 more source
The Primary Cilium: A Small Yet Mighty Organelle [PDF]
Journal of Investigative Dermatology, 2009 Primary cilia are small, cylindrical membrane protrusions on most vertebrate cell types. Despite an unassuming appearance, this organelle has proven to be a veritable nexus of tightly regulated cell-signal reception between the epithelium and mesenchyme. In this issue, Lehman et al.
DeRouen, Mindy C., Oro, Anthony E.
openaire +2 more sources
Advanced Science, EarlyView.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
The role of primary cilia in neuronal function
Neurobiology of Disease, 2010 The “ciliopathies” are a newly defined group of disorders characterized by defects in the structure or function of the cellular primary cilium. Patients with these disorders display variably expressive fibrocystic renal disease, retinal blindness ...
Jeong Ho Lee, Joseph G. Gleeson
doaj +1 more source
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
core +3 more sources
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons
Science Advances, 2020 Newborn neurons assemble a new primary cilium, leading to a change in the mode of Shh signaling that now directs axon extension. Cellular differentiation leads to the formation of specialized cell types and complex morphological variations.
G. Toro-Tapia, Raman M. Das
semanticscholar +1 more source
Dynamics of the Primary Cilium in Shear Flow [PDF]
Biophysical Journal, 2012 In this work, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both theoretical modeling and experiment. The cilium is modeled as an elastic beam that may undergo large deflection due to the hydrodynamic load. Equilibrium results show that the anchoring effects of the basal body on the cilium axoneme behave as
Young, Y.-N., Downs, M., Jacobs, C.R.
openaire +3 more sources
Advanced Science, EarlyView.We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha +13 more
wiley +1 more source