Results 151 to 160 of about 5,628,138 (356)
Realizing the physics of motile cilia synchronization with driven colloids
, 2015 Cilia and flagella in biological systems often show large scale cooperative behaviors such as the synchronization of their beats in "metachronal waves".
Bruot, Nicolas, Cicuta, Pietro
core +1 more source
The FEBS Journal, 2020 The primary cilium is a microtubule‐based structure that protrudes from the cell surface in diverse eukaryotic organisms. It functions as a key signaling center that decodes a variety of mechanical and chemical stimuli and plays fundamental roles in ...
Deniz Conkar, E. N. Firat-Karalar
semanticscholar +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Scientific Reports, 2017 The morphogenic factor Sonic hedgehog (Shh) signals through the primary cilium, which relies on intraflagellar transport to maintain its structural integrity and function.
Jie Ding +7 more
doaj +1 more source
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation [PDF]
, 2015 The base of the primary cilium contains a zone of condensed membranes whose importance is not known. Here, we have studied the involvement of MAL, a tetraspanning protein that exclusively partitions into condensed membrane fractions, in the condensation ...
Alonso, M.A. +9 more
core +2 more sources
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
BMC Cell Biology, 2008 Background Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia.
Wang Weiping, Brautigan David L
doaj +1 more source
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
, 2018 Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
core +3 more sources
Mechanosensation and the primary cilium
The FASEB Journal, 2008 The primary cilium has come under increased scrutiny as a site for mechano‐ and chemosensation by cells. We have undertaken a program of study using mouse renal cell lines from the cortical collecting duct and to quantify how mechanical forces arising from fluid shear transduce to a cellular response.
openaire +1 more source
Mechanisms of cell proliferation through primary cilium
Folia Pharmacologica Japonica, 2019 Primary cilium is a membrane-protruding sensory organelle, which is organized from a basal body in G0/G1 phase cells. The resorption of primary cilia under specific growth factor stimuli is coupled to cell cycle re-entry and cell proliferation, and the proliferative function is vital for the organization of organs at an embryonic stage.
Masaki, Saito, Wataru, Otsu
openaire +3 more sources