Results 131 to 140 of about 4,814,966 (373)
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source
Spontaneous creation of macroscopic flow and metachronal waves in an array of cilia [PDF]
, 2006 Cells or bacteria carrying cilia on their surface show many striking features : alignment of cilia in an array, two-phase asymmetric beating for each cilium, coordination between cilia and existence of metachronal waves with a constant phase difference between two adjacent cilia.
arxiv +1 more source
Internal friction controls active ciliary oscillations near the instability threshold [PDF]
Science Advances 6 (33), eabb0503 (2020), 2019 Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal elastic stress through a ...
arxiv +1 more source
Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]
, 2019 The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A +9 more
core +1 more source
Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
Ontogenetic shifts in olfactory rosette morphology of the sockeye salmon, Oncorhynchus nerka
Journal of Morphology, Volume 284, Issue 1, January 2023., 2023 Scanning electron microscope images of sockeye salmon olfactory rosette. Olfactory rosette size linearly increases with lamellae number throughout ontogeny. The complexity of the rosette, including the distribution of sensory and nonsensory epithelia, and the appearance of secondary lamellar folding, varies between fry and adult life stages.
Sarah E. Rheinsmith +3 more
wiley +1 more source
TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
Cell Reports, 2013 Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis.
Christian Alexandro Clement +10 more
doaj +1 more source
Mathematical Biosciences and Engineering, 2021 Primary cilia are non-motile, solitary (one per cell) microtubule-based organelles that emerge from the mother centriole after cells have exited the mitotic cycle.
Zhangli Peng +2 more
doaj +1 more source
The Vertebrate Primary Cilium in Development, Homeostasis, and Disease [PDF]
Cell, 2009 Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of
Nicholas Katsanis +2 more
openaire +3 more sources
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source