Results 151 to 160 of about 4,814,966 (373)

Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis. [PDF]

PLoS ONE, 2013
Adipose-derived stem cells (ASC) are multipotent stem cells that show great potential as a cell source for osteogenic tissue replacements and it is critical to understand the underlying mechanisms of lineage specification.
Josephine C Bodle, Candace D Rubenstein, Michelle E Phillips, Susan H Bernacki, Jie Qi, Albert J Banes, Elizabeth G Loboa   +6 more
doaj   +1 more source

Mathematical embryology: the fluid mechanics of nodal cilia [PDF]

arXiv, 2010
Left-right symmetry breaking is critical to vertebrate embryonic development; in many species this process begins with cilia-driven flow in a structure termed the `node'. Primary `whirling' cilia, tilted towards the posterior, transport morphogen-containing vesicles towards the left, initiating left-right asymmetric development.
arxiv  

Collective beating of artificial microcilia [PDF]

, 2011
We combine technical, experimental and theoretical efforts to investigate the collective dynamics of artificial microcilia in a viscous fluid. We take advantage of soft-lithography and colloidal self-assembly to devise microcapets made of hundreds of slender magnetic rods.
arxiv   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Anderson, Barker, Bellis, Bettencourt-Dias, Bowman, Brawley, Buczacki, Cabernard, Cairns, Callaini, Cao, Carmena, Castanon, Castanon, Chen, Cheng, Chrétien, Clevers, Conduit, Conti, Das, Delgehyr, Doe, Du, Durand, Falconer, Gillies, Gonzalez, Goulas, Graser, Habib, Hotz, Hsu, Inke Näthke, Ishikawa, Izumi, Izumi, Januschke, Januschke, Januschke, Jauffred, Jens Januschke, Johnston, Juanes, Kai, Knoblich, Konno, Kouzarides, Lander, Lansdorp, Lechler, Lerit, Liakopoulos, Lim, Lu, Lu, Lécuyer, Mapelli, Merdes, Moore, Morin, Morin, Morrison, Neumüller, Nigg, Nipper, Ouellet, Paridaen, Pelletier, Pereira, Piel, Postiglione, Potten, Poulson, Quyn, Razafsky, Rebollo, Rebollo, Regan, Reiter, Rocheteau, Rogers, Rusan, Sato, Segalen, Segalen, Shaw, Shitamukai, Siller, Siller, Smith, Speicher, Tajbakhsh, Takeda, Tian, Tran, Vorobjev, Wall, Wang, Wang, Wang, Werts, Williams, Wu, Yadlapalli, Yadlapalli, Yamashita, Yamashita, Yamashita, Yennek, Yoshiura, Yu, Zou   +112 more
core   +2 more sources

Exploring the Spectrum of Kidney Ciliopathies

Diagnostics, 2020
Ciliopathies are a group of multi-organ diseases caused by the disruption of the primary cilium. This event leads to a variety of kidney disorders, including nephronophthisis, renal cystic dysplasia, and renal cell carcinoma (RCC).
Matteo Santoni, Francesco Piva, Alessia Cimadamore, Matteo Giulietti, Nicola Battelli, Rodolfo Montironi, Laura Cosmai, Camillo Porta   +7 more
doaj   +1 more source

Long-Pentraxin 3 Affects Primary Cilium in Zebrafish Embryo and Cancer Cells via the FGF System

Cancers, 2020
Primary cilium drives the left-right asymmetry process during embryonic development. Moreover, its dysregulation contributes to cancer progression by affecting various signaling pathways.
J. Guerra, P. Chiodelli, C. Tobia, C. Gerri, M. Presta   +4 more
semanticscholar   +1 more source

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

Asymmetric Rotational Stroke in Mouse Node Cilia during Left-Right Determination [PDF]

, 2012
Clockwise rotational movement of isolated single cilia in mice embryo was investigated in vivo. The movement generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward unidirectional flow results from tilting of the rotational axis of the cilium to posterior side.
arxiv   +1 more source

A systems-biology approach to understanding the ciliopathy disorders. [PDF]

, 2011
'Ciliopathies' are an emerging class of genetic multisystemic human disorders that are caused by a multitude of largely unrelated genes that affect ciliary structure/function.
Gleeson, Joseph G, Lee, Ji Eun
core   +1 more source