Results 161 to 170 of about 18,376 (272)

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Mouse Odf2 localizes to centrosomes and basal bodies in adult tissues and to the photoreceptor primary cilium [PDF]

, 2009
Stephanie Schweizer, Sigrid Hoyer‐Fender   +1 more
openalex   +1 more source

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model

Pediatric Investigation, EarlyView.
THBA (3α,6α,7α,12α‐Tetrahydroxy‐10β,13β‐pentanoic acid) administration can alleviate cholestatic liver injury, hepatocellular necrosis, inflammatory response, bile duct hyperplasia, and portal fibrosis in the Zfyve19−/− mouse model. This evaluation encompasses various parameters, including serum biochemistry, liver histology, immunostaining, and ...
Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang   +8 more
wiley   +1 more source

The primary cilium as a multifunctional organelle: emerging roles and unanswered questions. [PDF]

Cell Commun Signal
Corbeil D, Thamm K, Karbanová J, Fargeas CA, Jászai J.   +4 more
europepmc   +1 more source

Primary Cilium Submicron Organization and Dynamics [PDF]

Biophysical Journal, 2020
Belén Torrado, Lorenzo Scipioni, Enrico Gratton, José L. Badano, Leonel S. Malacrida, Florencia Irigoín   +5 more
openaire   +1 more source

Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix

, 2014
Pattie S. Mathieu, Josephine C. Bodle, Elizabeth G. Loboa   +2 more
openalex   +1 more source

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts [PDF]

, 2010
Linda Schneider, Michael Cammer, Jonathan M. Lehman, Sonja Nielsen, Charles Guerra, Iben R. Veland, Christian Stock, Else K. Hoffmann, Bradley K. Yoder, Albrecht Schwab, Peter Satir, Søren T. Christensen   +11 more
openalex   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Correction: The primary cilium as a multifunctional organelle: emerging roles and unanswered questions. [PDF]

Cell Commun Signal
Corbeil D, Thamm K, Karbanová J, Fargeas CA, Jászai J.   +4 more
europepmc   +1 more source

Micropatterned Surfaces with Unidirectional Wetting Properties for Liquid Transport

Small Structures, EarlyView.
Micropatterned surfaces that guide droplets in a single direction are gaining attention for their role in liquid transport. This review explores how surface designs enable such behavior, from gravity‐driven flow to stimulus‐responsive movement. It also discusses fabrication techniques, design challenges, and emerging strategies to advance directional ...
Elham Lori Zoudani, Prabuddha De Saram, Stefanie Feih, Hoang Huy Vu, Nam‐Trung Nguyen, Navid Kashaninejad   +5 more
wiley   +1 more source