Results 81 to 90 of about 2,532,218 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Allergies: Primary healthcare

South African Family Practice, 1981
No abstract available.
openaire   +1 more source

Barriers and enablers to using evidence-based antibiotic prescription guidelines in primary care: a qualitative systematic review and synthesis using the theoretical domains framework

Implementation Science Communications
Background Antibiotics are commonly overprescribed for upper respiratory tract infections (URTIs) in primary care against widely known guideline recommendations. To design an effective intervention to improve adherence to URTI guideline-based care, it is
Krystal Bursey, Andrea M. Patey, Holly Etchegary, Kris Aubrey-Bassler, Victoria Kavanagh, Andrea Pike, Kristen Romme, Jeremy M. Grimshaw, Amanda Hall   +8 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Homecare workers - an untapped resource in preventing emergency department visits among older individuals? A qualitative interview study from Sweden

BMC Geriatrics
Background Older individuals with functional decline and homecare are frequent visitors to emergency departments (ED). Homecare workers (HCWs) interact regularly with their clients and may play a crucial role in their well-being.
Pia Bastholm-Rahmner, Monica Bergqvist, Karin Modig, Lars L. Gustafsson, Katharina Schmidt-Mende   +4 more
doaj   +1 more source

Isolated Hypogonadotropic Hypogonadism in a Young Woman with Primary Amenorrhoea

Oman Medical Journal
We describe a case of a young woman who presented with delayed secondary sexual development and primary amenorrhoea. She had low levels of oestradiol, follicle-stimulating hormone, and luteinizing hormone with normal levels of other pituitary hormones ...
Zalkha Al Kharusi, Nadia Al Mabaihsi, Amani Al Rawahi, Abeer Al Hadhrami, Maisa Al Kiyumi, Almundher Al-Maawali, Abdulaziz Al Mahrezi   +6 more
doaj   +1 more source

A protocol for a systematic review of clinical guidelines and published systematic reviews on the early detection of oral cancer [PDF]

, 2016
Background: The predicted increase in incidence of oral cavity cancer (OCC) coupled with high mortality and poor prognosis – particularly when diagnosed at a late/advanced stage – highlights the need for prevention and early detection/screening to ...
Al Bulushi, Naeema M., Conway, David I., Gibson, John, Macpherson, Lorna M.D., Ross, Alastair J., Worlledge-Andrew, Heather   +5 more
core   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Facilitators and Barriers to Scaling-Up Integrated Care for Arterial Hypertension and Type 2 Diabetes in Slovenia: Qualitative Study

Slovenian Journal of Public Health
Arterial hypertension and type 2 diabetes are significant contributors to global non-communicable disease-related mortality. Integrated care, centred on person-centred principles, aims to enhance healthcare quality and access, especially for vulnerable ...
ZAVRNIK Črt, STOJNIĆ Nataša, MORI LUKANČIČ Majda, MIHEVC Matic, VIRTIČ POTOČNIK Tina, KLEMENC-KETIŠ Zalika, POPLAS SUSIČ Antonija   +6 more
doaj   +1 more source

Access to healthcare for people seeking and refused asylum in Great Britain: a review of evidence [PDF]

, 2018
This research report is a review of evidence looking at the barriers people seeking or refused asylum face in trying to access healthcare services in the UK, and what may help them to do so more easily.
Friedland, J, Hargreaves, S, Hiam, L, Miller, A, Nellums, LB, Rustage, K   +5 more
core