Results 31 to 40 of about 4,497,204 (150)

Primary hyperaldosteronism

Journal of Medical and Scientific Research, 2016
Primary aldosteronism is caused by autonomous production of aldosterone by the adrenal cortex (due to hyperplasia, adenoma, or carcinoma). It is the cause of most common secondary form of arterial hypertension. The most common causes (90%) of primary aldosteronism are aldosterone producing adenomas and bilateral adrenal hyperplasia.
Panduranga G, Lekkala R, Griddaluru VC, Sujatha K   +3 more
openaire   +3 more sources

Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Regular monitoring of urinary electrolyte excretion and kidney function is essential in children with intestinal failure (IF) receiving long‐term parenteral nutrition (PN). This study evaluated alternative urine sampling methods against 24‐h urine collection (UC) and assessed the prevalence of chronic kidney disease (CKD) and renal ...
Anna Sakaeva, Andreas Busch, Johannes Holle, Hendrik Bartolomaeus, Bernd Fode, Ilias Tsiflikas, Ekkehard Sturm, Christoph Slavetinsky, Simon Scherer, Jörg Fuchs, Justus Lieber, Steven W. Warmann, Johannes Hilberath   +12 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Pseudo hyperaldosteronism secondary to herbal medicine use

, 2022
Glycyrrhizic acid, better known as licorice, is commonly found in various food and cosmetic products. Excessive consumption is known to cause a syndrome of apparent mineralocorticoid excess or pseudo hyperaldosteronism.
Syed Mohammad Mazhar Uddin, Shapiro, Joshua, Raashid, Sheharyar, Omair Khan, Joshua Shapiro, Kaur, Avleen, Armando Seitillari, Muhammad Hashim, Avleen Kaur, Hashim, Muhammad, Khan, Omair, Uddin, Syed Mohammad Mazhar, Seitillari, Armando, Saipriya Vasudevan, Lu, Tiffany, Vasudevan, Saipriya, Tiffany Lu, Sheharyar Raashid   +17 more
core   +1 more source

Histopathological stratification of primary aldosteronism using the CYP11B2 size ratio: first evaluation in clinical routine

Histopathology, Volume 89, Issue 6, Page 1011-1019, December 2026.
CYP11B2 immunohistochemistry identifies aldosterone‐producing nodules and enables objective subtyping using the B2 ratio (B2R), defined as the size ratio between the largest and second‐largest CYP11B2‐positive nodules. A B2R ≥8.1 indicates classical histology with a dominant lesion and high likelihood of cure, whereas B2R <8.1 reflects non‐classical ...
Adam Stenman, Tim Nilsson, Henrik Falhammar, C. Christofer Juhlin   +3 more
wiley   +1 more source

A Case of Deoxycorticosterone-Producing Adrenocortical Carcinoma: A Review of Etiologies of Hypertension With Hypokalemia

Annals of Internal Medicine: Clinical Cases
Resistant hypertension with hypokalemia can occur in patients with secondary hypertension with a differential diagnosis that includes primary hyperaldosteronism, secondary hyperaldosteronism, and pseudohyperaldosteronism. Herein, we report a rare case of
Farid Arman, Salila Kurra, Zhe Ran Susan Duan, Eric Siddall   +3 more
doaj   +1 more source

Primary Hyperaldosteronism and Renal Medullary Nephrocalcinosis: A Controversial Association

Oman Medical Journal, 2021
Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5–10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma.
Raiz Ahmad Misgar, Arun Viswanath S, Arshad Iqbal Wani , Mir Iftikhar Bashir   +3 more
doaj   +1 more source

A Giant 5000 g Primary Adrenocortical Carcinoma: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Adrenocortical carcinoma (ACC) is an aggressive malignancy that may present without hormonal symptoms. A 64 years old woman with abdominal pain, weight loss, and anemia had a massive adrenal tumor that required complex surgery. ACC should be considered in large abdominal masses. Complete surgical resection is essential.
Sadin Zahra, Aghajanzadeh Manouchehr, Mohammad Reza Sadin, Dadashi Arsalan, Poorsafar Mahdi, Aghzadeh Zeynab, Khyabani Mahmood, Shafaghi Afshin   +7 more
wiley   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source