Results 41 to 50 of about 8,998 (169)

Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5463-5475, July 2026.
ABSTRACT Cardiovascular‐kidney‐metabolic (CKM) syndrome is defined by the pathologic interconnections between obesity, diabetes, chronic kidney disease and cardiovascular disease. An important and underrecognized pathophysiologic factor underlying CKM syndrome is obesity‐induced aldosterone excess.
Evan Zeitler, Klara R. Klein, Ildiko Lingvay, Anthony Pick, Liana K. Billings   +4 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography‐Tandem Mass Spectrometry

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Steroids are critical for numerous physiological processes; disruption in their metabolism is associated with numerous endocrine disorders. Steroid quantification is essential to improve the understanding and diagnosis of these pathologies. Historically, urinary steroid profiling has been performed using low‐throughput gas chromatography mass ...
Joshua T. Bain, Fozia Shaheen, Alessandro Prete, Lorna C. Gilligan, Angela E. Taylor   +4 more
wiley   +1 more source

Resistant Hypertension: A Clinical Case

Revista Ciencias de la Salud, 2018
Introduction: Secondary hypertension corresponds to 15 % of the causes of arterial hypertension, and among them, primary hyperaldosteronism presents a variable incidence of about 3% in hypertensive patients.
Joana Cascais Costa, João Rua Rua, Amílcar Silva, Adriano Rodrigues   +3 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Conn's Syndrome, Subclinical Cushing's Syndrome and Thyrotoxicosis Presenting as Hypokalemic Periodic Paralysis: A Case Report - Case Report

Endocrinology Research and Practice, 2009
Thyrotoxicosis and primary hyperaldosteronism both cause hypokalemic periodic paralysis. Here we report a 51-year-old woman presenting with severe hypokalemia due to both thyrotoxicosis and primary hyperaldosteronism.
İnan Anaforoğlu, Alimdar Şimşek, Ekrem Algün   +2 more
doaj   +2 more sources

Familial hyperaldosteronism

Brazilian Journal of Medical and Biological Research, 2000
Aldosterone, the major circulating mineralocorticoid, participates in blood volume and serum potassium homeostasis. Primary aldosteronism is a disorder characterised by hypertension and hypokalaemia due to autonomous aldosterone secretion from the ...
D.J. Torpy, C.A. Stratakis, G.P. Chrousos   +2 more
doaj   +1 more source

A Diagnostic Pitfall of Primary Aldosteronism Presenting as Recurrent Quadriparesis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Quadriparesis refers to weakness affecting all four limbs. While most cases are neurogenic in origin, stemming from central or peripheral nervous system pathology, non‐neurogenic causes are less common and often under‐recognized. These include systemic or metabolic conditions that secondarily impair neuromuscular function.
Javed Shakir, Javeria Benyamin, Muhammad Usman Iqbal, Abdullah Sohail, Aafaq Mazhar, Hafiz Muhammad Abdullah, Erum Habib, Naseeb Danaf   +7 more
wiley   +1 more source

A Young Patient with Leg Weakness and Hypokalemia—Case Report

Rambam Maimonides Medical Journal, 2018
A 20-year-old female patient was admitted to hospital because of bilateral leg weakness. Laboratory investigation showed metabolic alkalosis and severe hypokalemia.
Elias Andrawus, Irit Hochberg, Zaher S. Azzam   +2 more
doaj   +1 more source

Prevalence and Severity of Coronary Artery Calcification Assessed by Low‐Dose Computed Tomography in Individuals With Type 2 Diabetes With and Without Diabetic Foot: A Cross‐Sectional Study

Journal of Diabetes, Volume 18, Issue 6, June 2026.
Diabetic foot is independently associated with the presence and severity of coronary artery calcification in patients with type 2 diabetes. Patients developing diabetic foot or with impaired renal function may warrant enhanced cardiovascular risk assessment and screening for silent coronary artery disease.
Feiyan Shi, Yun Gao, Mingxin Bai, Ruixue Feng, Chunjie Ma, Dawei Chen, Chun Wang, Lihong Chen, Sen He, Donge Yan, Chunchao Xia, Xingwu Ran   +11 more
wiley   +1 more source