Results 101 to 110 of about 298,517 (337)

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Editorial: The role of transcription factors in inborn errors of immunity

Frontiers in Immunology, 2023
Delfien J. Bogaert, Delfien J. Bogaert, Hye Sun Kuehn, Victoria Bordon, Filomeen Haerynck, Filomeen Haerynck   +5 more
doaj   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, EarlyView.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

Mild Hypogammaglobulinemia Can Be a Serious Condition

Frontiers in Immunology, 2018
Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD).
Lisanne M. A. Janssen, Paul Bassett, Thomas Macken, Jolanda van Esch, Hans Pruijt, Arnoud Knoops, Markus Sköld, Antony Parker, Jolanda de Vries, Esther de Vries, Esther de Vries   +10 more
doaj   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Autosomal recessive hyper‐IgE syndrome due to DOCK8 deficiency: An adjunctive role for omalizumab

Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 222-226, December 2022., 2022
We report a rare case of AR‐HIES with DOCK8 deficiency in a young male that was successfully treated by infection management, skincare, diet elimination, and omalizumab. Abstract Autosomal recessive hyper‐IgE syndrome (AR‐HIES) is a rare primary immunodeficiency disorder characterized by high serum IgE levels, recurrent viral skin infections, severe ...
Kim Han Nguyen, Quynh Anh Nguyen, Mai Hoang Tran, Thu Thuy Can, Mai Thi Vu, Nam Sy Vo, Hieu Chu Chi, Sheryl van Nunen, Dinh Van Nguyen   +8 more
wiley   +1 more source

Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
S. J. Tavernier, V. Athanasopoulos, P. Verloo, G. Behrens, J. Staal, D. J. Bogaert, L. Naesens, M. De Bruyne, S. Van Gassen, E. Parthoens, J. Ellyard, J. Cappello, L. X. Morris, H. Van Gorp, G. Van Isterdael, Y. Saeys, M. Lamkanfi, P. Schelstraete, J. Dehoorne, V. Bordon, R. Van Coster, B. N. Lambrecht, B. Menten, R. Beyaert, C. G. Vinuesa, V. Heissmeyer, M. Dullaers, F. Haerynck   +27 more
doaj   +1 more source

Arthritis in primary immunodeficiencies

Bolʹ, Sustavy, Pozvonočnik, 2017
The article deals with joint diseases in patients with primary immunodeficiencies. The analysis of the li­terature data based on Scopus, Science Index, Google Scholar, PubMed databases accentuated primary immunodeficiencies associated with the joint ...
O.R. Boyarchuk, L.A. Volyanska, T.A. Kovalchuk, M.I. Kinash   +3 more
doaj   +1 more source

Human Immunodeficiency Virus(HIV) Cases in the Philippines: Analysis and Forecasting [PDF]

JP Journal of Biostatistics, 16(2), 67-77, 2019, 2019
Reports from the Health Department in the Philippines show that cases of Human Immunodeficiency Virus (HIV) are increasing despite management and control efforts by the government. Worldwide, the Philippines has one of the fastest growing number of HIV cases.
arxiv