Results 211 to 220 of about 483,399 (234)

Approach to primary immunodeficiency

Allergy and Asthma Proceedings, 2019
Primary immunodeficiency diseases are inherited defects of the innate or adaptive arms of the immune system that lead to an increase in the incidence, frequency, or severity of infections and/or immune dysregulation. There may be defects in the adaptive arm of the immune system, including combined immunodeficiencies and antibody deficiency syndromes ...
Ashley L Devonshire, Melanie M. Makhija
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Primary Immunodeficiency Diseases

1976
Rare individuals, experiments of nature who suffer the often devastating consequences of a congenital defect within the immune system, have served to teach us much of what we know today about the complex immune response of man (36,39,54). From a careful study of them and their diseases, together with related studies in the laboratory, we have learned ...
Robert A. Good, M. A. Hansen
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Malakoplakia and Primary Immunodeficiency

The Journal of Pediatrics, 2014
Malakoplakia, a rare granulomatous disease caused by impaired macrophage response, has been reported only rarely in children. We report 3 unique cases, with lesions occurring in unusual locations in children with primary immune deficiencies.
Sydney R. Archer, Carlos R. Abramowsky, Lisa Kobrynski, Stephen Simoneaux, Larry B. Vogler, Richard R. Ricketts, Cecily Parker, Nancy Elawahbdeh, Bahig M. Shehata   +8 more
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Primary immunodeficiency

2013
In general, immunodeficiencies are divided into those of the specific immune system (e.g. T cells or B cells or combined) or those of the innate or non-specific immune system (e.g. complement and neutrophils). Immunodeficiencies may also be divided into primary (usually genetic) and secondary, where the immune defect is caused by some other non ...
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Progress in primary immunodeficiency

Immunology Today, 1992
Clinically, primary immunodeficiencies can be grouped into several well-defined syndromes. This consistent clinical picture, however, belies the enormous complexity of lymphocyte maturation and activation, and it has long been suspected that numerous distinct underlying defects give rise to primary immunodeficiencies.
Richard B. Gallagher, Yuichi Taguchi, Yukio Sakiyama, Tadashi Ariga, Shuzo Matsumoto   +4 more
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Primary T-cell immunodeficiencies

Current Opinion in Immunology, 1993
The phenotypes of many primary T-cell immunodeficiencies have been described, including diseases associated with defective T-cell differentiation and/or activation. Recently, genotypes have been defined for some of them, such as X-linked severe combined immunodeficiency and CD3 deficiencies (or hyper IgM syndrome).
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PRIMARY IMMUNODEFICIENCY DISORDERS [PDF]

Primary Care: Clinics in Office Practice, 1998
The primary immunodeficiency diseases are a relatively rare group of congenital disorders that are linked by the expression of an excessive number, duration, or severity of infections. The clinical features of most of the primary immunodeficiency diseases have been well described by astute physicians over several decades and have provided important ...
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Primary Immunodeficiency Syndromes

2010
Several DNA repair pathways have evolved to recognise and repair DNA damaged by exogenous and endogenous agents, in order to maintain genomic integrity. Defects in these pathways can lead to replication errors, loss or rearrangement ofgenomic material, mutation or cancer and eventual death.
Mary Slatter, Andrew R. Gennery
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Primary Immunodeficiencies of Horses

Veterinary Clinics of North America: Equine Practice, 2000
Primary immunodeficiency disorders are genetically determined failures of immune defense that increase susceptibility to infectious agents. This article reviews the salient features of equine primary immunodeficiency disorders, summarizes the molecular mechanisms of each disorder, and updates information that facilitates diagnosis and management of ...
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Primary cellular immunodeficiencies

Journal of Allergy and Clinical Immunology, 2002
Genetic defects in T-cell function lead to susceptibility to infections or to other clinical problems that are more grave than those seen in disorders resulting in antibody deficiency alone. Those affected usually present during infancy with either common or opportunistic infections and rarely survive beyond infancy or childhood. The spectrum of T-cell
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