Results 221 to 230 of about 220,119 (313)

Safety, Tolerability, and Pharmacokinetics of the Long‐Acting SARS‐CoV‐2–Neutralizing Monoclonal Antibody Combination AZD7442 (Tixagevimab/Cilgavimab) in Healthy Chinese Adults

Clinical Pharmacology in Drug Development, EarlyView.
Abstract AZD7442, a combination of extended half‐life monoclonal antibodies tixagevimab and cilgavimab, was shown to neutralize previously circulating SARS‐CoV‐2 variants. This study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 in healthy Chinese adults. In this randomized, placebo‐controlled, Phase 1 study, AZD7442
Nanyang Li, Jing Zhang, Wenhong Zhang, Zhongyuan Xu, Xiangcao Yao, Anqi He, Shuyuan Liu, Xiaoyun Ge, Jinxi Liu, Yunfei Li, Cecil Chi‐Keung Chen, Huixia Zhang   +11 more
wiley   +1 more source

A patient empowerment program for primary immunodeficiency improves quality of life in children and adolescents. [PDF]

Immunotherapy
Fasshauer M, Schuermann G, Gebert N, Bernuth HV, Bullinger M, Goldacker S, Krueger R, Manzey P, Messner S, Renner ED, Ritterbusch H, Schauer U, Schulze I, Umlauf V, Widmann S, Baumann U.   +15 more
europepmc   +1 more source

OMIP‐116: A 39‐Color Full Spectrum Flow Cytometric Panel to Deeply Characterize Human Thymopoiesis

Cytometry Part A, EarlyView.
ABSTRACT We report the development of a 39‐color (43‐parameter) full spectrum flow cytometry panel designed and optimized to deeply characterize the intrathymic development of human conventional and unconventional T cells. The panel was designed using strategies dictated by best practices for full spectrum and multiparametric flow cytometry, and was ...
Simone Balin, Paolo Marzano, Daniele Manganaro, Anna Villa, Paolo Andrea Zucali, Domenico Mavilio, Silvia Della Bella   +6 more
wiley   +1 more source

Automated analysis of flow cytometry data with minimal training files: Research evaluation of an elastic image registration algorithm for TBNK, stem cell enumeration, and lymphoid screening tube assays

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Automated analysis of flow cytometry data can improve objectivity and reduce analysis time but has generally required work by software and algorithm experts. Here, we investigated the performance of BD ElastiGate™ Software (hereafter ElastiGate), which allows users to automate gating by selecting gated training files, then uses elastic image ...
Allison Irvine, Suhail Tahir, Vishnu Tripathi, Farzad Oreizy, Moen Sen, Anthony Giuliano, Anna Lin, Angela Chen, Chih‐Hung Lai, Imelda Omana‐Zapata, Yang Zeng, Paresh Jain, Scott J. Bornheimer   +12 more
wiley   +1 more source

Mechanism and target treatment of primary immunodeficiency diseases with systemic lupus erythematosus-like phenotype. [PDF]

Pediatr Discov
Liu S, Zhang Z, Tang X, Zhao X, An Y.
europepmc   +1 more source

PRIMARY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION DURING PREGNANCY ASSOCIATED WITH TRANSMISSION OF SI/MT-2 CELL TROPIC VIRUS AND PRECIPITOUS LOSS OF CD4 CELLS IN MOTHER AND INFANT

, 1998
Lorenz von Seidlein, Susan Plaeger, Ruth Dickover, Paul Krogstad, E. Richard Stiehm, Yvonne J. Bryson   +5 more
openalex   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

A single-center experience of COVID-19 infection in patients with primary immunodeficiency. [PDF]

J Allergy Clin Immunol Glob
Zhou JJ, Jin C, Leang ZX, Chatelier J, Godsell J, Tsang S, Douglass JA, Yong MK, Slavin M, Bryant VL, Slade CA, Chan S.   +11 more
europepmc   +1 more source