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Immunodeficiency and Multiple Primary Malignancies [PDF]
The relationship between cancer onset and the immune response became a subject of great interest in the early 1900s, and led Ehrlich [1] to establish what came to be known as the theory of immunological surveillance. This theory is based on three principles: (1) cancer cells are antigenic, (2) these cells can be destroyed by the immune response of the ...
SANTANGELO, MICHELE +13 more
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Primary Immunodeficiency in the NICU
NeoReviews, 2019Primary immunodeficiency disorders (PIDs) are genetic diseases that lead to increased susceptibility to infection. Hundreds of PIDs have now been described, but a select subset commonly presents in the neonatal period. Neonates, especially premature newborns, have relative immune immaturity that makes it challenging to differentiate PIDs from intrinsic
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Primary Immunodeficiency Diseases
JAMA: The Journal of the American Medical Association, 1997Primary immunodeficiencies are rare, but important for 3 reasons. First, a high index of suspicion and prompt diagnosis can lead to lifesaving treatment or significant improvement in quality of life. Second, appreciation of the genetic nature of a host defense defect makes possible family counseling and carrier and prenatal diagnosis.
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Primary immunodeficiencies and the rheumatologist
Current Opinion in Rheumatology, 2003Fabio Candotti +2 more
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Approach to Primary Immunodeficiency
Allergy and Asthma Proceedings, 1993Chyung Sy, Evans R rd
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