Results 41 to 50 of about 5,426,861 (329)

Primary Immunodeficiencies [PDF]

, 2008
Primary immunodeficiencies (PIDs), once considered to be very rare, are now increasingly recognized because of growing knowledge in the immunological field and the availability of more sophisticated diagnostic techniques and therapeutic modalities [161].
Elizabeth Drewe, Richard Powell
openaire   +2 more sources

A Computational Pipeline for the Diagnosis of CVID Patients

Frontiers in Immunology, 2019
Common variable immunodeficiency (CVID) is one of the most frequently diagnosed primary antibody deficiencies (PADs), a group of disorders characterized by a decrease in one or more immunoglobulin (sub)classes and/or impaired antibody responses caused by
Annelies Emmaneel, Annelies Emmaneel, Delfien J. Bogaert, Delfien J. Bogaert, Sofie Van Gassen, Sofie Van Gassen, Simon J. Tavernier, Simon J. Tavernier, Simon J. Tavernier, Melissa Dullaers, Filomeen Haerynck, Filomeen Haerynck, Yvan Saeys, Yvan Saeys   +13 more
doaj   +1 more source

Update in Primary Immunodeficiencies.

Acta bio-medica : Atenei Parmensis, 2020
Primary immunodeficiencies (PIDs) are inherited disorders classically characterized by increased susceptibility to infections. Nevertheless, in the last two decades, genomic analysis (such as NGS) coupled with biochemical and cellular studies led to a more accurate definition for a growing number of novel genetic disorders associated with PIDs.
Leonardi, Lucia, Rivalta, Beatrice, Cancrini, Caterina, Chiappini, Elena, Cravidi, Claudio, Caffarelli, Carlo, Manti, Sara, Calvani, Mauro, Martelli, Alberto, Miraglia Del Giudice, Michele, Duse, Marzia, Marseglia, Gian Luigi, Cardinale, Fabio   +12 more
openaire   +4 more sources

Hematopoietic Stem Cell Transplantation in Primary Immunodeficiency Diseases: Current Status and Future Perspectives

Frontiers in Pediatrics, 2019
Primary immunodeficiencies (PID) are disorders that for the most part result from mutations in genes involved in immune host defense and immunoregulation.
Riccardo Castagnoli, O. Delmonte, Enrica Calzoni, L. Notarangelo   +3 more
semanticscholar   +1 more source

Comparison of [3H]-Thymidine, Carboxyfluorescein Diacetate Succinimidyl Ester and Ki-67 in Lymphocyte Proliferation

Frontiers in Pediatrics, 2022
BackgroundPatients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT).
Hsin-Ju Lee, Chun-Chun Gau, Chun-Chun Gau, Chun-Chun Gau, Wan-Fang Lee, Wen-I Lee, Wen-I Lee, Jing-Long Huang, Jing-Long Huang, Jing-Long Huang, Shih-Hsiang Chen, Ho-Yu Yeh, Chi-Jou Liang, Shih-Hang Fu   +13 more
doaj   +1 more source

Autoimmunity as a continuum in primary immunodeficiency

Current opinion in pediatrics, 2019
Purpose of review Primary immunodeficiency disorders (PIDs) are no longer defined by infections alone. First clinical sign or sequelae of PID may include autoimmunity, such as cytopenias, arthritis or enteropathy.
J. Walter, Irmel A. Ayala, D. Milojevic
semanticscholar   +1 more source

Whole exome sequencing identifies compound heterozygous variants of gene in monozygotic twin patients with common variable immunodeficiency

SAGE Open Medicine, 2020
Objectives: A pair of female Malay monozygotic twins who presented with recurrent upper respiratory tract infections, hepatosplenomegaly, bronchiectasis and bicytopenia were recruited in this study.
Adiratna Mat Ripen, Hamidah Ghani, Chai Teng Chear, Mei Yee Chiow, Sharifah Nurul Husna Syed Yahya, Asiah Kassim, Saharuddin Bin Mohamad   +6 more
doaj   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years

Allergy, Asthma & Clinical Immunology, 2021
Background A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would establish clinical characteristics,
Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Iean Hamzah Sendut, Thiyagar Nadarajaw, Faizah Mohamed Jamil, David C. E. Ng, Mohd Azri Zainal Abidin   +22 more
doaj   +1 more source

Prevalence of Intestinal Parasitic Infection in Cancer, Organ Transplant and Primary Immunodeficiency Patients in Tehran, Iran

Asian Pacific Journal of Cancer Prevention, 2019
Background: Intestinal parasitic infection in immunodeficient patients especially those with impaired cellular immunity, like neoplasia, renal or heart transplant needs careful consideration.
A. Esteghamati, Khadijeh Khanaliha, F. Bokharaei-Salim, S. Sayyahfar, Masoomeh Ghaderipour   +4 more
semanticscholar   +1 more source