Results 61 to 70 of about 117,096 (113)

12. Primary immunodeficiency diseases

Journal of Allergy and Clinical Immunology, 2003
Although primary immunodeficiency disorders are relatively rare, intensive investigation of these disorders has yielded a great wealth of understanding of basic immunologic mechanisms in host defense, inflammation, and autoimmunity. These advances have led to important developments for the treatment not only of the primary immunodeficiencies but also ...
Francisco A. Bonilla, Raif S. Geha
openaire   +3 more sources

Neutropenia and Primary Immunodeficiency Diseases

International Reviews of Immunology, 2009
Primary immunodeficiency diseases (PID) are a heterogeneous group of congenital disorders of the immune system leading to recurrent infections, autoimmunity, malignancies, and hematological disorders. This review focuses specifically on inherited disorders associated with neutropenia, which may occur in isolation or as a feature of more complex immune ...
Asghar Aghamohammadi, Kasra Moazzami, Christoph Klein, Nima Rezaei   +3 more
openaire   +2 more sources

Primary immunodeficiency diseases: An update

Journal of Allergy and Clinical Immunology, 2004
Although relatively rare, primary immune deficiency diseases (PIDs) provide an excellent window into the functioning of the immune system. In the late 1960s, observations on these diseases, with their associated infections and genetics, bisected the immune system into humoral immunity and cell-mediated immunity.
Reinhard Seger, Raif S. Geha, Alain Fischer, Luigi D. Notarangelo, Jennifer M. Puck, Fred S. Rosen, Jean-Laurent Casanova   +6 more
openaire   +3 more sources

Primary Immunodeficiency Diseases

JAMA: The Journal of the American Medical Association, 1997
Primary immunodeficiencies are rare, but important for 3 reasons. First, a high index of suspicion and prompt diagnosis can lead to lifesaving treatment or significant improvement in quality of life. Second, appreciation of the genetic nature of a host defense defect makes possible family counseling and carrier and prenatal diagnosis.
openaire   +3 more sources

Primary immunodeficiency diseases in adulthood

Internal Medicine Journal, 2004
Abstract Occasionally, patients present with clinical episodes of infectious disease that seem to fall beyond the scope of normal immunocompetence. Examples include infections that are unusually persistent, recurrent or resistant to treatment, or those involving unexpected dissemination of disease or atypical pathogens.
Sandhya Limaye, D. S. Riminton
openaire   +3 more sources

Mycobacterial diseases in primary immunodeficiencies

Current Opinion in Allergy and Clinical Immunology, 2001
Primary immunodeficiency diseases comprise over 100 conditions, each associated with a variety of viral, bacterial, fungal and protozoan infections. M. tuberculosis and less virulent mycobacteria, such as bacille Calmette-Guérin vaccines and environmental non-tuberculous mycobacteria, may cause severe disease in patients with primary immunodeficiency ...
Sergio D. Rosenzweig, Rainer Doffinger, Steven M. Holland, Stéphanie Dupuis, Jean-Laurent Casanova, Janine Reichenbach   +5 more
openaire   +3 more sources

History of primary immunodeficiency diseases

Current Opinion in Allergy & Clinical Immunology, 2012
This issue of Current Opinion in Allergy and Clinical Immunology is focused on primary immunodeficiency diseases (PIDs). Like every disorder, PID has its own specific history, starting with the discovery of agammaglobulinemia in 1952 and still expanding at a rapid pace, covering, at the time of this publication, more than 180 genetically determined ...
Hans D. Ochs, Walter H. Hitzig
openaire   +2 more sources

Liver Disease in Primary Immunodeficiencies

Journal of Hepatology, 2000
Primary immunodeficiencies (PIDs) are heritable disorders of innate and/or acquired immunity, often complicated by severe, recurrent or unusual infections, chronic diarrhea with failure to thrive and malignancies of lymphoid tissue in long-term survivors.
openaire   +2 more sources

Primary Immunodeficiency Diseases

2019
Primary immunodeficiency diseases (PIDs) are a heterogeneous group of monogenic disorders in which part of the immune system is deficient or does not function properly. Patients with PID commonly present with recurrent infections, which explains the importance of the immune system in protection from organisms.
Mohammed F. Essa, Mohammed F. Essa, Fayhan Alroqi, Fayhan Alroqi, Abdulrahman Alsultan   +4 more
openaire   +2 more sources

Primary immunodeficiency diseases

The Nurse Practitioner, 2015
Primary care providers (PCPs) play a key role in identifying patients with primary immunodeficiency diseases (PIDDs). This diagnosis has implications for PCPs, as patients continue to require primary care and management after a PIDD diagnosis has been made. This review presents essential information for PCPs regarding PIDDs.
Elizabeth M. Younger, Kristin Epland, Mary Hintermeyer, Annette R. Zampelli   +3 more
openaire   +3 more sources